Determining the Role of Immunoglobulin Levels in Children with Febrile Seizures.

BACKGROUND

Febrile seizures are the most common form of convulsive disorder in childhood. The mechanisms underlying the pathogenesis of febrile seizure remain unclear.

OBJECTIVE

The aim of this study was to assess the immunoglobulin (IG) sub-group levels in children with febrile seizures.

METHODS AND MATERIAL: The patients with a diagnosis of febrile seizure with an age range of 1-7 years who attended the clinic were included in the study. Neurologically normal and age- and sex-matched children with no history of febrile seizures were considered as controls.

RESULTS

A total of 64 patients and 100 control subjects participated in this study. There were no significant inter-group differences in terms of sex and age of the participants (p >.05). There was no statistical difference between case and control groups for serum lymphocyte count, IgA, IgG, IgM, IgE levels, and anti-HB response (p >.05).

CONCLUSION

Our study demonstrated that there is no difference in humoral immunity between children with febrile seizures and control subjects with the same age range.