Epilepsy & behavior : E&B · 2019
Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project.
СтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Rivera Bonet Charlene N, Hermann Bruce, Cook Cole J, Hwang Gyujoon, Dabbs Kevin, Nair Veena, Forseth Courtney, Mathis Jedidiah, Allen Linda, Almane Dace N, Arkush Karina, Birn Rasmus, Conant Lisa L, DeYoe Edgar A, Felton Elizabeth, Humphries Colin J, Kraegel Peter, Maganti Rama, Nencka Andrew, Nwoke Onyekachi, Raghavan Manoj, Rozman Megan, Shah Umang, Sosa Veronica N, Struck Aaron F, Tellapragada Neelima, Ustine Candida, Ward B Douglas, Prabhakaran Vivek, Binder Jeffrey R, Meyerand Mary E
Аннотация
Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.