Медицинская библиотека · Head & neck · 2024

Parameningeal Rhabdomyosarcoma: Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 Study.

Schoot Reineke A, Taselaar Pieter, Scarzello Giovanni, Kolb Frederic, Coppadoro Beatrice, Horst Simone Ter, Mandeville Henry, Ferrari Andrea, Hladun Raquel, Helfre Sylvie, Ferman Sima, Kelsey Anna, Hol Marinka L F, Devalck Christine, Ben-Arush Myriam, Orbach Daniel, Chisholm Julia, Jenney Meriel, Minard-Colin Veronique, Bisogno Gianni, Merks Johannes H M

СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Parameningeal (PM) site is an unfavorable characteristic in rhabdomyosarcoma (RMS). We described the treatment and outcome for patients with PM RMS and investigated the prognostic value of risk factors. We scored PM site by originating site and by highest risk extension.

METHODS

Patients with PM RMS were treated within the European pediatric Soft tissue sarcoma Study Group (EpSSG) RMS 2005 study with risk-adapted, multi-modal treatment.

RESULTS

Three-hundred-eighty-one patients with PM RMS were included. Radiotherapy was administered in 359 patients (77 with surgery). After a median follow-up of 75 months, 5-year event-free survival was 60% (95% confidence interval (CI) 55%-65%), 5-year overall survival was 65% (95% CI 60%-70%).

CONCLUSIONS

The outcome for patients with PM RMS has not improved in comparison to previous historical studies, despite the more rigorous application of radiotherapy (94% of patients). Signs of meningeal involvement, PM site, and age at diagnosis remained prognostic risk factors.

TRIAL REGISTRATION: EudraCT number 2005-000217-35.

Для цитирования: Schoot Reineke A, Taselaar Pieter, Scarzello Giovanni, Kolb Frederic, Coppadoro Beatrice, Horst Simone Ter, Mandeville Henry, Ferrari Andrea, Hladun Raquel, Helfre Sylvie, Ferman Sima, Kelsey Anna, Hol Marinka L F, Devalck Christine, Ben-Arush Myriam, Orbach Daniel, Chisholm Julia, Jenney Meriel, Minard-Colin Veronique, Bisogno Gianni, Merks Johannes H M. Parameningeal Rhabdomyosarcoma: Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 Study.. Head & neck. 2024. DOI: 10.1002/hed.27994.

Предметные рубрики MeSH

Humans Rhabdomyosarcoma Female Male Child Child, Preschool Infant Adolescent Europe Prognosis Combined Modality Therapy Disease-Free Survival Treatment Outcome Meningeal Neoplasms Risk Factors Survival Analysis

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