Lassa fever in post-conflict sierra leone.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shaffer Jeffrey G, Grant Donald S, Schieffelin John S, Boisen Matt L, Goba Augustine, Hartnett Jessica N, Levy Danielle C, Yenni Rachael E, Moses Lina M, Fullah Mohammed, Momoh Mambo, Fonnie Mbalu, Fonnie Richard, Kanneh Lansana, Koroma Veronica J, Kargbo Kandeh, Ottomassathien Darin, Muncy Ivana J, Jones Abigail B, Illick Megan M, Kulakosky Peter C, Haislip Allyson M, Bishop Christopher M, Elliot Deborah H, Brown Bethany L, Zhu Hu, Hastie Kathryn M, Andersen Kristian G, Gire Stephen K, Tabrizi Shervin, Tariyal Ridhi, Stremlau Mathew, Matschiner Alex, Sampey Darryl B, Spence Jennifer S, Cross Robert W, Geisbert Joan B, Folarin Onikepe A, Happi Christian T, Pitts Kelly R, Geske F Jon, Geisbert Thomas W, Saphire Erica Ollmann, Robinson James E, Wilson Russell B, Sabeti Pardis C, Henderson Lee A, Khan S Humarr, Bausch Daniel G, Branco Luis M, Garry Robert F, Viral Hemorrhagic Fever Consortium
Аннотация
METHODOLOGY/PRINCIPAL FINDINGS: Clinical and laboratory records of patients presenting to the KGH Lassa Ward in the post-conflict period were organized electronically. Recombinant antigen-based LF immunoassays were used to assess LASV antigenemia and LASV-specific antibodies in patients who met criteria for suspected LF. KGH has been reestablished as a center for LF treatment and research, with over 500 suspected cases now presenting yearly. Higher case fatality rates (CFRs) in LF patients were observed compared to studies conducted prior to the civil conflict. Different criteria for defining LF stages and differences in sensitivity of assays likely account for these differences. The highest incidence of LF in Sierra Leone was observed during the dry season. LF cases were observed in ten of Sierra Leone's thirteen districts, with numerous cases from outside the traditional endemic zone. Deaths in patients presenting with LASV antigenemia were skewed towards individuals less than 29 years of age. Women self-reporting as pregnant were significantly overrepresented among LASV antigenemic patients. The CFR of ribavirin-treated patients presenting early in acute infection was lower than in untreated subjects.
CONCLUSIONS/SIGNIFICANCE: Lassa fever remains a major public health threat in Sierra Leone. Outreach activities should expand because LF may be more widespread in Sierra Leone than previously recognized. Enhanced case finding to ensure rapid diagnosis and treatment is imperative to reduce mortality. Even with ribavirin treatment, there was a high rate of fatalities underscoring the need to develop more effective and/or supplemental treatments for LF.