Operative neurosurgery (Hagerstown, Md.) · 2025
Increased Risk of Permanent Speech Production Deficits Following Resection of the Dominant Ventral Precentral Gyrus Compared With Broca's Area.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Yuyao, Yan Peisong, Zhao Zehao, Zhang Jie, Lu Junfeng
Аннотация
BACKGROUND AND OBJECTIVES: Accumulating evidence supports the ventral precentral gyrus (vPrCG) as the true seat of speech production instead of Broca's area, but the exact scope of language impact following damage to each remains unclear. To provide detailed causal observation, we compared the short-term and long-term effects on language function following localized resections of the dominant vPrCG and Broca's area.
METHODS: Aphasia Battery of Chinese evaluation at preoperation, 1-month, and 3-month postoperation was conducted in 40 right-handed glioma patients who underwent resection within the left posterior inferior frontal lobe. The cohort included a posterior inferior frontal gyrus (pIFG) group (n = 16) with resections confined to Broca's area, a vPrCG group (n = 24) with resections involving the vPrCG, and a control group of healthy subjects (n = 44). For subgroup analysis, a vPrCG-only group (n = 12) was defined by excluding cases with resections extension into pIFG.
RESULTS: The vPrCG group showed significantly higher aphasia rate (62.5%, P = .0064) and lower Aphasia Quotient (86.3 ± 12.6, P = .0092) compared with the pIFG group (18.8%, 96.6 ± 3.1) at 3 months postoperation. The vPrCG group also demonstrated long-term impairments across multiple speech production-related domains, including fluency ( P = .0038) of spontaneous speech, oral instructions ( P = .0003) of comprehension, repetition ( P = .0098), and naming ( P = .0040). At 1-month postoperation, no patients in the pIFG group scored below 70 in Aphasia Quotient, whereas 10 of 24 vPrCG patients did, with some showing minimal recovery by 3 months. Lasso regression identified spontaneous speech and naming as predictors of long-term language outcome for vPrCG and pIFG groups, respectively. Subgroup analysis confirmed findings from the overall vPrCG group.
CONCLUSION: Resection of vPrCG rather than Broca's area leads to greater risk of postoperative language deficits and poorer long-term recovery in speech production-related functions.
METHODS: Aphasia Battery of Chinese evaluation at preoperation, 1-month, and 3-month postoperation was conducted in 40 right-handed glioma patients who underwent resection within the left posterior inferior frontal lobe. The cohort included a posterior inferior frontal gyrus (pIFG) group (n = 16) with resections confined to Broca's area, a vPrCG group (n = 24) with resections involving the vPrCG, and a control group of healthy subjects (n = 44). For subgroup analysis, a vPrCG-only group (n = 12) was defined by excluding cases with resections extension into pIFG.
RESULTS: The vPrCG group showed significantly higher aphasia rate (62.5%, P = .0064) and lower Aphasia Quotient (86.3 ± 12.6, P = .0092) compared with the pIFG group (18.8%, 96.6 ± 3.1) at 3 months postoperation. The vPrCG group also demonstrated long-term impairments across multiple speech production-related domains, including fluency ( P = .0038) of spontaneous speech, oral instructions ( P = .0003) of comprehension, repetition ( P = .0098), and naming ( P = .0040). At 1-month postoperation, no patients in the pIFG group scored below 70 in Aphasia Quotient, whereas 10 of 24 vPrCG patients did, with some showing minimal recovery by 3 months. Lasso regression identified spontaneous speech and naming as predictors of long-term language outcome for vPrCG and pIFG groups, respectively. Subgroup analysis confirmed findings from the overall vPrCG group.
CONCLUSION: Resection of vPrCG rather than Broca's area leads to greater risk of postoperative language deficits and poorer long-term recovery in speech production-related functions.