Медицинская библиотека · Transactions of the Royal Society of Tropical Medicine and Hygiene · 2020

The impact of empirical hydrocortisone therapy on clinical outcomes in dengue fever: a retrospective chart review.

de Mel Sanjay, Thilakawardana Basuru Uvindu, de Mel Primesh, de Silva Arjuna P, de Mel Chandima, Chandrasena Lal, Seneviratne Suranjith L, Abeysuriya Visula

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Аннотация

BACKGROUND

The role of steroids in dengue infection (DI) remains uncertain.

METHODS

A retrospective chart review was conducted on patients ≥18 y of age diagnosed with DI based on positivity for dengue non-structural antigen 1 or immunoglobulin M between October 2017 and November 2018.

RESULTS

Hydrocortisone was administered to 106 of 406 patients. DI with warning signs occurred in nine patients (9.5%) in the steroid cohort and eight patients (2.5%) in the non-steroid group. The incidence of severe DI, bleeding and admission duration were similar between the groups.

CONCLUSIONS

Our study shows no significant benefit of empirical steroids in DI.

Для цитирования: de Mel Sanjay, Thilakawardana Basuru Uvindu, de Mel Primesh, de Silva Arjuna P, de Mel Chandima, Chandrasena Lal, Seneviratne Suranjith L, Abeysuriya Visula. The impact of empirical hydrocortisone therapy on clinical outcomes in dengue fever: a retrospective chart review.. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2020. DOI: 10.1093/trstmh/traa049.

Предметные рубрики MeSH

Cohort Studies Dengue Hemorrhage Humans Hydrocortisone Retrospective Studies Severe Dengue

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