Journal of the American Academy of Dermatology · 2016
Sex differences in the association of cutaneous melanoma incidence rates and geographic ultraviolet light exposure.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод в очереди
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Liu-Smith Feng, Farhat Ahmed Majid, Arce Anthony, Ziogas Argyrios, Taylor Thomas, Wang Zi, Yourk Vandy, Liu Jing, Wu Jun, McEligot Archana J, Anton-Culver Hoda, Meyskens Frank L
Аннотация
BACKGROUND: Cutaneous melanoma (CM) incidence rates continue to increase, and the reasons are unknown. Previously, we reported a unique age-specific sex difference in melanoma that suggested additional causes other than solar ultraviolet (UV) radiation.
OBJECTIVE: This study attempted to understand whether and how UV radiation differentially impacts the CM incidence in men and women.
METHODS: CM data and daily UV index (UVI) from 31 cancer registries were collected for association analysis. A second dataset from 42 US states was used for validation.
RESULTS: There was no association between log-transformed female CM rates and levels of UVI, but there was a significant association between male rates and UVI and a significant association between overall rates and UVI. The 5-year age-specific rate-UVI association levels (represented by Pearson's coefficient ρ) increased with age in men, but age-specific ρ levels remained low and unchanged in women. The significant rate-UVI association in men and nonassociation in women was validated in a population of white residents of the United States.
LIMITATIONS: Confounders, including temperature and latitude, are difficult to separate from UVI.
CONCLUSIONS: Ambient UVI appears to be associated with melanoma incidence in males but not in females.
OBJECTIVE: This study attempted to understand whether and how UV radiation differentially impacts the CM incidence in men and women.
METHODS: CM data and daily UV index (UVI) from 31 cancer registries were collected for association analysis. A second dataset from 42 US states was used for validation.
RESULTS: There was no association between log-transformed female CM rates and levels of UVI, but there was a significant association between male rates and UVI and a significant association between overall rates and UVI. The 5-year age-specific rate-UVI association levels (represented by Pearson's coefficient ρ) increased with age in men, but age-specific ρ levels remained low and unchanged in women. The significant rate-UVI association in men and nonassociation in women was validated in a population of white residents of the United States.
LIMITATIONS: Confounders, including temperature and latitude, are difficult to separate from UVI.
CONCLUSIONS: Ambient UVI appears to be associated with melanoma incidence in males but not in females.