[Developmental outcomes of very preterm and extremely preterm infants at the 12 months corrected age].

OBJECTIVE

To establish effect of Cortexin for development outcomes of preterm neonates born with low and extremely low body weight, with perinatal pyramidal tract (PT) damage.

MATERIAL AND

METHODS

127 children born with very low body weight and extremely low body weight were examined. I group - 22 infant with damage to the PT, treating non-drug rehabilitation during the first year. II group - 59 infant with damage to the PT, treating non-drug rehabilitation and Cortexin during the first year. III control group - 46 infant without structural changes according DTI MRI. Neurodevelopmental outcomes was evaluated by using the INFANIB scale at the 12 months corrected age.

RESULTS

Significant differences were found between groups. The results showed that at the correct age of 12 months normal neurodevelopment occurred more often in two times in second group (1 group - 18.2%, 2 group - 40.7%, p<0.05). Almost of children from control group had normal psychomotor development (3 group - 93.5%). Cerebral palsy was noted significantly more often in the first group (1 group - 36.4%, 3 group - 13.6%, p<0.05).

CONCLUSIONS

DTI MRI has high prognostic value for very preterm and extremely preterm infants. In the same time, we can observe better development outcomes with damage to the PT in the group of children treating non-drug rehabilitation and Cortexin during the first year.