Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span.
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Habel Ute, Reif Andreas, Herpertz Sabine, Konrad Kerstin, Freitag Christine, Banaschewski Tobias, Frodl Thomas, Barnes-Scheufler Catherine, Berg Lisa, Bertsch Katja, Chechko Natalya, Chiocchetti Andreas G, Ecker Christine, Ende Gabriele, Fritsch Antonia, Gramegna Chiara, Hanke Michael, Holz Nathalie, Hüpen Philippa, Kuschel Ina, Mathiak Klaus, Maas Annika, Meyer-Lindenberg Andreas, Neukel Corinne, Paret Christian, Plichta Michael, Reindl Vanessa, Retz Wolfgang, Scharf Jaqueline, Schmahl Christian, Schirok Henry, Tost Heike, Turner Daniel, Tüscher Oliver, Wagels Lisa, Weidler Carmen, Zweerings Jana
Аннотация
METHODS: Capitalizing on the Research Domain Criteria "negative valence system" (NVS) and "cognitive system" (CS), multilevel measurements of behavioral and biological systems provide a harmonized dataset at three study sites (Frankfurt, Mannheim/Heidelberg, Aachen; 900 adults, 200 children/youth) including forensic satellites (n = 150). A cross-sectional matched control group (300 adults, 100 youth) will also be included.
DISCUSSION: The goal of the study is to provide a multilevel characterization of patients, assessing dimensional phenotypic measures across time points and diagnoses, to finally define aggressive biosignatures.
TRIAL REGISTRATION: The present study has been registered at https://drks.de/register/en/trial/DRKS00035731 (number of registration: DRKS00035731; date of registration: 20/02/2025).