Editorial: When Null Is Not Nothing: Mechanism and Moderation in Youth Alcohol Use Disorder.

In psychiatry, we rarely lack treatments. However, we frequently lack treatments that are informed by disorder-specific mechanisms or by the stage of an illness. As clinicians, we choose from an armamentarium that includes individual psychotherapies, family-based interventions, supplements, a cornucopia of psychotropic classes, digital therapeutics, and neuromodulation-based treatments. Our choice of treatment is ideally based on evidence and experience, but treatment selection may also be influenced by how we conceptualize the psychology and pathobiology of the disorder we are treating. However, when our biological model of an illness is incomplete, treatment becomes empirical.