Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Gnörich Johannes, Kusche-Palenga Julia, Palleis Carla, Neubauer Antonia, Frontzkowski Lukas, Jäck Alexander, Kling Agnes, Bauer Theresa, Eyob Hannah, Probst Katharina, Roemer-Cassiano Sebastian N, Bernhardt Alexander M, Katzdobler Sabrina, Marth Lena, Zaganjori Mirlind, Hopfner Franziska, Zwergal Andreas, Häckert Jan, Rullmann Michael, Sabri Osama, Barthel Henryk, Stöcklein Sophia, Werner Rudolf A, Simons Mikael, Levin Johannes, Herms Jochen, Franzmeier Nicolai, Höglinger Günter U, Brendel Matthias, German Imaging Initiative for Tauopathies (GII4T)
Аннотация
METHODS: Twenty-three PSP patients underwent two [18F]PI-2620 PET scans (interval: 21.4 ± 4.3 months) and were compared to cross-sectional data from 25 healthy controls. Regional volume of distribution ratio values were analyzed for longitudinal tau changes, clinical correlations, and network-based propagation. Post mortem analyses examined neuronal density and AT8 tau pathology.
RESULTS: Subcortical tau PET signals increased, strongest in the globus pallidus internus (P < 0.0001). Patients with low baseline tau showed the largest increases. Despite clinical worsening (Progressive Supranuclear Palsy Rating Scale +48%), tau PET change did not correlate with symptom progression. Tau accumulation followed functional connectivity (R = 0.34, P < 0.0001). Post mortem data linked elevated tau PET to higher AT8 burden despite neuronal loss.
DISCUSSION: [18F]PI-2620 PET enables monitoring of tau progression in PSP, indicating network-based tau propagation with saturation in advanced stages.