Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
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Bräuer Stefan, Sondermann Verena, Schniewind Iñaki, Hähnel Tom, Dinter Elisabeth, Kleineidam Luca, Stark Melina, Schmid Matthias, Sodenkamp Sebastian, Laske Christoph, Spruth Eike, Priller Josef, Janowitz Daniel, Bürger Katharina, Kilimann Ingo, Teipel Stefan, Storch Alexander, Hansen Niels, Wiltfang Jens, Glanz Wenzel, Düzel Emrah, Preis Lukas, Peters Oliver, Hellmann-Regen Julian, Wagner Michael, Bernhardt Alexander, Levin Johannes, Petzold Gabor, Kronmüller Marie, Gamez Anna, Spottke Annika, Brosseron Frederic, Rostamzadeh Ayda, Jessen Frank, Hermann Andreas, Fliessbach Klaus, Schneider Anja, Falkenburger Björn H
Аннотация
METHODS: In addition to the "standard" SAA, we developed a quantitative SAA (qnSAA) and measured 432 CSF samples (216 baseline-follow-up pairs).
RESULTS: qnSAA results correlated with cognitive performance. Seventy-five percent of participants with fast qnSAA kinetics converted to dementia in the observed interval. Overall, participants with fast qnSAA kinetics accounted for 27.3% of dementia converters in the entire cohort.
DISCUSSION: Findings demonstrate promising properties of qnSAA measurements in a cohort of patients at risk for dementia. qnSAA results showed improved prognostic relevance and have potential to measure target engagement of therapies against Lewy body pathology.