NeuroImage · 2026
A nap can recalibrate homeostatic and associative synaptic plasticity in the human cortex.
СтатьяНазвание и аннотация: Перевод в очереди
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Fehér Kristoffer D, Henckaerts Pauline, Hirsch Valentin, Bucsenez Ulrike, Kuhn Marion, Maier Jonathan G, Schneider Carlotta L, Hertenstein Elisabeth, Mikutta Christian, Riemann Dieter, Feige Bernd, Nissen Christoph
Аннотация
BACKGROUND: Nighttime sleep renormalizes net synaptic strength (homeostatic plasticity) and the inducibility of long-term potentiation (LTP)-like plasticity (associative plasticity) in the cortex. However, whether an afternoon nap is sufficient for this process remains to be characterized.
METHODS: Twenty healthy adults participated in a repeated measures sleep laboratory study with an adaptation and two experimental sessions - nap and wake (1:15-2:15 pm). After the nap or wake session, non-invasive indices of net synaptic strength (indexed by transcranial magnetic stimulation, TMS-probed corticospinal excitability and wake EEG theta activity) and inducibility of LTP-like plasticity (indexed by TMS-induced motor evoked potentials, MEPs, following paired associative stimulation, PAS) were assessed.
RESULTS: We observed indices of reduced net synaptic strength after sleep compared to wakefulness, evidenced by a higher TMS intensity needed to induce MEPs and reduced wake EEG theta activity. Additionally, we observed an increase in the inducibility of associative synaptic plasticity after sleep, as evidenced by a greater increase in TMS-induced MEPs in response to PAS.
CONCLUSIONS: The study reinforces the restorative effect of sleep for homeostatic and associative synaptic plasticity in the human cortex and demonstrates that even a short nap can promote this process.
METHODS: Twenty healthy adults participated in a repeated measures sleep laboratory study with an adaptation and two experimental sessions - nap and wake (1:15-2:15 pm). After the nap or wake session, non-invasive indices of net synaptic strength (indexed by transcranial magnetic stimulation, TMS-probed corticospinal excitability and wake EEG theta activity) and inducibility of LTP-like plasticity (indexed by TMS-induced motor evoked potentials, MEPs, following paired associative stimulation, PAS) were assessed.
RESULTS: We observed indices of reduced net synaptic strength after sleep compared to wakefulness, evidenced by a higher TMS intensity needed to induce MEPs and reduced wake EEG theta activity. Additionally, we observed an increase in the inducibility of associative synaptic plasticity after sleep, as evidenced by a greater increase in TMS-induced MEPs in response to PAS.
CONCLUSIONS: The study reinforces the restorative effect of sleep for homeostatic and associative synaptic plasticity in the human cortex and demonstrates that even a short nap can promote this process.