Addiction (Abingdon, England) · 2025
Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Del Cerro-León Alberto, Uceta Marcos, Shpakivska-Bilan Danylyna, Suárez-Méndez Isabel, Peribáñez-Baz Héctor, Cuesta Pablo, Bruña Ricardo, García-Moreno Luis M, Maestú Fernando, Antón-Toro Luis Fernando
Аннотация
AIMS: To identify the brain activity profiles associated with alcohol consumption and to address its causes. Furthermore, we sought to examine the relationship between these electrophysiological markers and the excitation-inhibition balance, as well as to explore the potential moderating role of sex in these associations.
DESIGN: Longitudinal study involving a neuroimaging assessment that included magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with a battery of self-report questionnaires. A follow-up assessment was conducted two years later using the same set of neuroimaging and behavioural measures.
SETTING AND PARTICIPANTS: 56 adolescents aged 13 to 17 years recruited from high schools in the community of Madrid, Spain, prior to the initiation of alcohol use.
MEASUREMENTS: We extracted measures of power spectral density and excitation-inhibition balance across the brain from MEG recordings and cognitive traits related to risk behaviors from a battery of self-report questionnaires. Alcohol consumption was evaluated during the follow-up visit through structured individual interviews.
FINDINGS: Power-spectra in beta-band showed a positive correlation with alcohol use during both stages (baseline: rho = 0.33, P < 0.05; follow-up: rho = 0.35; P < 0.05) and a negative correlation with excitation-inhibition ratio (baseline: P < 0.001; rho = -0.56; follow-up: P < 0.01; rho = -0.37). Finally, biological sex showed strong moderation effect, where females drove the predictive relationship (P < 0.001; rho = 0.64; β = -0,61).
CONCLUSION: Spontaneous electrophysiological brain activity may provide an early biomarker of future alcohol use in females and appears to be associated with activity profiles prone to inhibition.
DESIGN: Longitudinal study involving a neuroimaging assessment that included magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with a battery of self-report questionnaires. A follow-up assessment was conducted two years later using the same set of neuroimaging and behavioural measures.
SETTING AND PARTICIPANTS: 56 adolescents aged 13 to 17 years recruited from high schools in the community of Madrid, Spain, prior to the initiation of alcohol use.
MEASUREMENTS: We extracted measures of power spectral density and excitation-inhibition balance across the brain from MEG recordings and cognitive traits related to risk behaviors from a battery of self-report questionnaires. Alcohol consumption was evaluated during the follow-up visit through structured individual interviews.
FINDINGS: Power-spectra in beta-band showed a positive correlation with alcohol use during both stages (baseline: rho = 0.33, P < 0.05; follow-up: rho = 0.35; P < 0.05) and a negative correlation with excitation-inhibition ratio (baseline: P < 0.001; rho = -0.56; follow-up: P < 0.01; rho = -0.37). Finally, biological sex showed strong moderation effect, where females drove the predictive relationship (P < 0.001; rho = 0.64; β = -0,61).
CONCLUSION: Spontaneous electrophysiological brain activity may provide an early biomarker of future alcohol use in females and appears to be associated with activity profiles prone to inhibition.