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DOI 10.1038/s41591-024-03459-9

Медицинская библиотека · Nature medicine · 2024

Genomic and transmission dynamics of the 2024 Marburg virus outbreak in Rwanda.

Butera Yvan, Mutesa Leon, Parker Edyth, Muvunyi Raissa, Umumararungu Esperance, Ayitewala Alisen, Musabyimana Jean Pierre, Olono Alhaji, Sesonga Placide, Ogunsanya Olusola, Kabalisa Emmanuel, Adedokun Oluwatobi, Gahima Nelson, Irankunda Laetitia, Mutezemariya Chantal, Niyonkuru Richard, Uwituze Arlene, Uwizera Ithiel, Kagame James, Umugwaneza Arlette, Rwabuhihi John, Umwanankabandi Fidele, Mbonitegeka Valens, Ntagwabira Edouard, Kayigi Etienne, Izuwayo Gerard, Murenzi Herve, Mukankwiro Therese, Tuyiringire Nasson, Uwimana Jean Marie Vianney, Gasengayire Agnes, Sindayiheba Reuben, Onyeugo Glory-Ugochi, Aragaw Merawi, Gitundu Lenny, Bigirimana Radjabu, Fallah Mosoka, Ejikeme Adaora, Sembuche Senga, Kabanda Alice, Mugisha Jean Claude, Francis Emmanuel Edwar Siddig, Gashema Pierre, Ndayisenga Jerome, Rugamba Alexis, Kanyabwisha Faustin, Murenzi Gad, Happi Anise, Ngabonziza Jean Claude Semuto, Gashegu Misbah, Ahmed Ayman, Bigirimana Noella, Rwagasore Edson, Semakula Muhammed, Rwabihama Jean Paul, Musanabaganwa Clarisse, Seruyange Eric, Nkeshimana Menelas, Twagirumugabe Theogene, Turatsinze David, Remera Eric, Gahamanyi Noel, Tessema Sofonias Kifle, Mukagatare Isabelle, Nsanzimana Sabin, Happi Christian, Muvunyi Claude Mambo

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Аннотация

The ongoing outbreak of Marburg virus disease in Rwanda marks the third largest historically, although it has shown the lowest fatality rate. Genomic analysis of samples from 18 cases identified a lineage with limited internal diversity, closely related to a 2014 Ugandan case. Our findings suggest that the Rwandan lineage diverged decades ago from a common ancestor shared with diversity sampled from bats in Uganda. Our genomic data reveal limited genetic variation, consistent with a single zoonotic transmission event and limited human-to-human transmission. Investigations including contact tracing, clinical assessments, sequencing and serology, linked the index case to a mining cave inhabited by Rousettus aegyptiacus. Serology tests identified three individuals seropositive for immunoglobulin G and immunoglobulin M, further supporting the zoonotic origin of the outbreak through human-animal interactions.

Для цитирования: Butera Yvan, Mutesa Leon, Parker Edyth, Muvunyi Raissa, Umumararungu Esperance, Ayitewala Alisen, Musabyimana Jean Pierre, Olono Alhaji, Sesonga Placide, Ogunsanya Olusola, Kabalisa Emmanuel, Adedokun Oluwatobi, Gahima Nelson, Irankunda Laetitia, Mutezemariya Chantal, Niyonkuru Richard, Uwituze Arlene, Uwizera Ithiel, Kagame James, Umugwaneza Arlette, Rwabuhihi John, Umwanankabandi Fidele, Mbonitegeka Valens, Ntagwabira Edouard, Kayigi Etienne, Izuwayo Gerard, Murenzi Herve, Mukankwiro Therese, Tuyiringire Nasson, Uwimana Jean Marie Vianney, Gasengayire Agnes, Sindayiheba Reuben, Onyeugo Glory-Ugochi, Aragaw Merawi, Gitundu Lenny, Bigirimana Radjabu, Fallah Mosoka, Ejikeme Adaora, Sembuche Senga, Kabanda Alice, Mugisha Jean Claude, Francis Emmanuel Edwar Siddig, Gashema Pierre, Ndayisenga Jerome, Rugamba Alexis, Kanyabwisha Faustin, Murenzi Gad, Happi Anise, Ngabonziza Jean Claude Semuto, Gashegu Misbah, Ahmed Ayman, Bigirimana Noella, Rwagasore Edson, Semakula Muhammed, Rwabihama Jean Paul, Musanabaganwa Clarisse, Seruyange Eric, Nkeshimana Menelas, Twagirumugabe Theogene, Turatsinze David, Remera Eric, Gahamanyi Noel, Tessema Sofonias Kifle, Mukagatare Isabelle, Nsanzimana Sabin, Happi Christian, Muvunyi Claude Mambo. Genomic and transmission dynamics of the 2024 Marburg virus outbreak in Rwanda.. Nature medicine. 2024. DOI: 10.1038/s41591-024-03459-9.

Предметные рубрики MeSH

RwandaHumansDisease OutbreaksAnimalsMarburgvirusMarburg Virus DiseasePhylogenyChiropteraMaleFemaleGenome, ViralAdultGenomicsGenetic VariationZoonoses
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