Revista medica de Chile · 2007
[Association between glutathione peroxidase levels and clinical manifestations of dengue].
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Rojas Elsa Marina, Díaz-Quijano Fredi Alexander, Coronel-Ruiz Carolina, Martínez-Vega Ruth Aralf, Rueda Ernesto, Villar-Centeno Luis Angel
Аннотация
BACKGROUND: Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases.
AIM: To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue.
PATIENTS AND METHODS: Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up.
RESULTS: Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L.
CONCLUSIONS: GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue.
AIM: To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue.
PATIENTS AND METHODS: Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up.
RESULTS: Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L.
CONCLUSIONS: GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue.