Медицинская библиотека · Brain imaging and behavior · 2017
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.
Guadalupe Tulio, Mathias Samuel R, vanErp Theo G M, Whelan Christopher D, Zwiers Marcel P, Abe Yoshinari, Abramovic Lucija, Agartz Ingrid, Andreassen Ole A, Arias-Vásquez Alejandro, Aribisala Benjamin S, Armstrong Nicola J, Arolt Volker, Artiges Eric, Ayesa-Arriola Rosa, Baboyan Vatche G, Banaschewski Tobias, Barker Gareth, Bastin Mark E, Baune Bernhard T, Blangero John, Bokde Arun L W, Boedhoe Premika S W, Bose Anushree, Brem Silvia, Brodaty Henry, Bromberg Uli, Brooks Samantha, Büchel Christian, Buitelaar Jan, Calhoun Vince D, Cannon Dara M, Cattrell Anna, Cheng Yuqi, Conrod Patricia J, Conzelmann Annette, Corvin Aiden, Crespo-Facorro Benedicto, Crivello Fabrice, Dannlowski Udo, de Zubicaray Greig I, de Zwarte Sonja M C, Deary Ian J, Desrivières Sylvane, Doan Nhat Trung, Donohoe Gary, Dørum Erlend S, Ehrlich Stefan, Espeseth Thomas, Fernández Guillén, Flor Herta, Fouche Jean-Paul, Frouin Vincent, Fukunaga Masaki, Gallinat Jürgen, Garavan Hugh, Gill Michael, Suarez Andrea Gonzalez, Gowland Penny, Grabe Hans J, Grotegerd Dominik, Gruber Oliver, Hagenaars Saskia, Hashimoto Ryota, Hauser Tobias U, Heinz Andreas, Hibar Derrek P, Hoekstra Pieter J, Hoogman Martine, Howells Fleur M, Hu Hao, Hulshoff Pol Hilleke E, Huyser Chaim, Ittermann Bernd, Jahanshad Neda, Jönsson Erik G, Jurk Sarah, Kahn Rene S, Kelly Sinead, Kraemer Bernd, Kugel Harald, Kwon Jun Soo, Lemaitre Herve, Lesch Klaus-Peter, Lochner Christine, Luciano Michelle, Marquand Andre F, Martin Nicholas G, Martínez-Zalacaín Ignacio, Martinot Jean-Luc, Mataix-Cols David, Mather Karen, McDonald Colm, McMahon Katie L, Medland Sarah E, Menchón José M, Morris Derek W, Mothersill Omar, Maniega Susana Munoz, Mwangi Benson, Nakamae Takashi, Nakao Tomohiro, Narayanaswaamy Janardhanan C, Nees Frauke, Nordvik Jan E, Onnink A Marten H, Opel Nils, Ophoff Roel, Paillère Martinot Marie-Laure, Papadopoulos Orfanos Dimitri, Pauli Paul, Paus Tomáš, Poustka Luise, Reddy Janardhan Yc, Renteria Miguel E, Roiz-Santiáñez Roberto, Roos Annerine, Royle Natalie A, Sachdev Perminder, Sánchez-Juan Pascual, Schmaal Lianne, Schumann Gunter, Shumskaya Elena, Smolka Michael N, Soares Jair C, Soriano-Mas Carles, Stein Dan J, Strike Lachlan T, Toro Roberto, Turner Jessica A, Tzourio-Mazoyer Nathalie, Uhlmann Anne, Hernández Maria Valdés, van den Heuvel Odile A, van der Meer Dennis, van Haren Neeltje E M, Veltman Dick J, Venkatasubramanian Ganesan, Vetter Nora C, Vuletic Daniella, Walitza Susanne, Walter Henrik, Walton Esther, Wang Zhen, Wardlaw Joanna, Wen Wei, Westlye Lars T, Whelan Robert, Wittfeld Katharina, Wolfers Thomas, Wright Margaret J, Xu Jian, Xu Xiufeng, Yun Je-Yeon, Zhao JingJing, Franke Barbara, Thompson Paul M, Glahn David C, Mazoyer Bernard, Fisher Simon E, Francks Clyde
СтатьяМногоцентровое исследованиеПеревод в очереди
Аннотация
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
Для цитирования: Guadalupe Tulio, Mathias Samuel R, vanErp Theo G M, Whelan Christopher D, Zwiers Marcel P, Abe Yoshinari, Abramovic Lucija, Agartz Ingrid, Andreassen Ole A, Arias-Vásquez Alejandro, Aribisala Benjamin S, Armstrong Nicola J, Arolt Volker, Artiges Eric, Ayesa-Arriola Rosa, Baboyan Vatche G, Banaschewski Tobias, Barker Gareth, Bastin Mark E, Baune Bernhard T, Blangero John, Bokde Arun L W, Boedhoe Premika S W, Bose Anushree, Brem Silvia, Brodaty Henry, Bromberg Uli, Brooks Samantha, Büchel Christian, Buitelaar Jan, Calhoun Vince D, Cannon Dara M, Cattrell Anna, Cheng Yuqi, Conrod Patricia J, Conzelmann Annette, Corvin Aiden, Crespo-Facorro Benedicto, Crivello Fabrice, Dannlowski Udo, de Zubicaray Greig I, de Zwarte Sonja M C, Deary Ian J, Desrivières Sylvane, Doan Nhat Trung, Donohoe Gary, Dørum Erlend S, Ehrlich Stefan, Espeseth Thomas, Fernández Guillén, Flor Herta, Fouche Jean-Paul, Frouin Vincent, Fukunaga Masaki, Gallinat Jürgen, Garavan Hugh, Gill Michael, Suarez Andrea Gonzalez, Gowland Penny, Grabe Hans J, Grotegerd Dominik, Gruber Oliver, Hagenaars Saskia, Hashimoto Ryota, Hauser Tobias U, Heinz Andreas, Hibar Derrek P, Hoekstra Pieter J, Hoogman Martine, Howells Fleur M, Hu Hao, Hulshoff Pol Hilleke E, Huyser Chaim, Ittermann Bernd, Jahanshad Neda, Jönsson Erik G, Jurk Sarah, Kahn Rene S, Kelly Sinead, Kraemer Bernd, Kugel Harald, Kwon Jun Soo, Lemaitre Herve, Lesch Klaus-Peter, Lochner Christine, Luciano Michelle, Marquand Andre F, Martin Nicholas G, Martínez-Zalacaín Ignacio, Martinot Jean-Luc, Mataix-Cols David, Mather Karen, McDonald Colm, McMahon Katie L, Medland Sarah E, Menchón José M, Morris Derek W, Mothersill Omar, Maniega Susana Munoz, Mwangi Benson, Nakamae Takashi, Nakao Tomohiro, Narayanaswaamy Janardhanan C, Nees Frauke, Nordvik Jan E, Onnink A Marten H, Opel Nils, Ophoff Roel, Paillère Martinot Marie-Laure, Papadopoulos Orfanos Dimitri, Pauli Paul, Paus Tomáš, Poustka Luise, Reddy Janardhan Yc, Renteria Miguel E, Roiz-Santiáñez Roberto, Roos Annerine, Royle Natalie A, Sachdev Perminder, Sánchez-Juan Pascual, Schmaal Lianne, Schumann Gunter, Shumskaya Elena, Smolka Michael N, Soares Jair C, Soriano-Mas Carles, Stein Dan J, Strike Lachlan T, Toro Roberto, Turner Jessica A, Tzourio-Mazoyer Nathalie, Uhlmann Anne, Hernández Maria Valdés, van den Heuvel Odile A, van der Meer Dennis, van Haren Neeltje E M, Veltman Dick J, Venkatasubramanian Ganesan, Vetter Nora C, Vuletic Daniella, Walitza Susanne, Walter Henrik, Walton Esther, Wang Zhen, Wardlaw Joanna, Wen Wei, Westlye Lars T, Whelan Robert, Wittfeld Katharina, Wolfers Thomas, Wright Margaret J, Xu Jian, Xu Xiufeng, Yun Je-Yeon, Zhao JingJing, Franke Barbara, Thompson Paul M, Glahn David C, Mazoyer Bernard, Fisher Simon E, Francks Clyde. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.. Brain imaging and behavior. 2017. DOI: 10.1007/s11682-016-9629-z.
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