American journal of ophthalmology · 2015
Photodynamic Therapy for Choroidal Metastasis.
Clinical StudyСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ghodasra Devon H, Demirci Hakan
Аннотация
PURPOSE: To evaluate the effectiveness of photodynamic therapy (PDT) in the management of choroidal metastasis.
DESIGN: Retrospective, interventional case series.
METHODS: Patients with choroidal metastasis treated with PDT at a single institution were reviewed. PDT was applied with verteporfin at a dose of 6 mg/m(2) body surface area and a 689 nm diode laser for 83 seconds. Visual acuity, tumor basal diameter, tumor thickness by ultrasonography, and enhanced depth imaging optical coherence tomography (EDI-OCT), as well as associated features including subretinal fluid, were recorded before PDT and during follow-up examinations.
RESULTS: Twenty-one tumors in 13 eyes of 10 patients were included. Eight tumors were treated with a single session of PDT, 11 tumors received 2 sessions, 1 tumor received 3 sessions, and 1 tumor received 5 sessions. At the end of a mean follow-up of 12 months (range, 3-42 months), 9 eyes (69%) had stable or improved visual acuity, while 4 eyes (31%) had decreased visual acuity. Mean logMAR change in visual acuity was -0.09 (range, -1.3 to 0.8). Seventeen of 21 tumors (81%) were flat at last follow-up. The mean decrease in ultrasound-measured thickness was 0.83 mm (range, 2.6 mm decrease to 1.4 mm increase), while the decrease in EDI-OCT-measured thickness was 400 μm (range, 1280 μm decrease to 280 μm increase). Eighteen tumors (86%) had complete resolution of subretinal fluid. There were no PDT-related complications.
CONCLUSIONS: Photodynamic therapy may be an effective therapeutic option for the management of choroidal metastasis in selected cases.
DESIGN: Retrospective, interventional case series.
METHODS: Patients with choroidal metastasis treated with PDT at a single institution were reviewed. PDT was applied with verteporfin at a dose of 6 mg/m(2) body surface area and a 689 nm diode laser for 83 seconds. Visual acuity, tumor basal diameter, tumor thickness by ultrasonography, and enhanced depth imaging optical coherence tomography (EDI-OCT), as well as associated features including subretinal fluid, were recorded before PDT and during follow-up examinations.
RESULTS: Twenty-one tumors in 13 eyes of 10 patients were included. Eight tumors were treated with a single session of PDT, 11 tumors received 2 sessions, 1 tumor received 3 sessions, and 1 tumor received 5 sessions. At the end of a mean follow-up of 12 months (range, 3-42 months), 9 eyes (69%) had stable or improved visual acuity, while 4 eyes (31%) had decreased visual acuity. Mean logMAR change in visual acuity was -0.09 (range, -1.3 to 0.8). Seventeen of 21 tumors (81%) were flat at last follow-up. The mean decrease in ultrasound-measured thickness was 0.83 mm (range, 2.6 mm decrease to 1.4 mm increase), while the decrease in EDI-OCT-measured thickness was 400 μm (range, 1280 μm decrease to 280 μm increase). Eighteen tumors (86%) had complete resolution of subretinal fluid. There were no PDT-related complications.
CONCLUSIONS: Photodynamic therapy may be an effective therapeutic option for the management of choroidal metastasis in selected cases.
Предметные рубрики MeSH
AdultAgedBreast NeoplasmsCarcinomaCarcinoma, Ductal, BreastCarcinoma, Non-Small-Cell LungCarcinoma, PapillaryChoroid NeoplasmsFemaleFollow-Up StudiesHumansLasersLung NeoplasmsMaleMiddle AgedPhotochemotherapyPhotosensitizing AgentsPorphyrinsRetrospective StudiesSubretinal FluidThyroid Cancer, PapillaryThyroid NeoplasmsTomography, Optical CoherenceVerteporfinVisual Acuity