Journal of visceral surgery · 2025
Does cholecystectomy in patients with sickle cell disease reduce vaso-occlusive crises? A study conducted in two referral hospitals in Niger.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Saïdou Adama, Boka Tounga Yahouza, Ide Kadi, Maman Bachir Abdoulaye, Zabeirou Oudou Aliou, Sani Rachid
Аннотация
UNLABELLED: The objective of this study was to report on the results of cholecystectomy in patients with sickle cell disease in two hospitals in Niger.
PATIENTS AND METHODS: This was a retrospective study conducted over a six-year period in the general referral hospital and the national hospital of Niamey (Niger).
RESULTS: We collected data concerning 56 cases of cholecystectomy in patients with sickle cell disease, representing of 10.3% of all cholecystectomies (gall bladder removals) performed. A majority of the patients were female (55.4%), with a mean age of 20.2 years, standard deviation of 8.8, and extreme values at 6 and 47 years. Homozygous SS forms of sickle cell disease predominated (92.9%). Nearly two-thirds of the patients (64.3%) were referred from the national sickle cell disease referral center. The main operative indication (69.6%) was symptomatic gall bladder (vesicular) lithiasis. All of the patients were anemic, with severe anemia in nearly half (44.6%). Exchange transfusion was carried out in 42.9% of the patients, and perioperative blood transfusion in 57.1%. The laparoscopic route was followed in almost all of the patients (94.6%). Mean postoperative stay in an intensive care unit was 23.5±7.2 (12-48) 48hours. The rate of postoperative complications was 23.2%, and the rate of mortality was 1.8%. As regards disease progress at one year, no vaso-occlusive crises were observed in seven eight (87.5) of the patients.
CONCLUSION: Cholecystectomy in sickle cell patients calls for a multidisciplinary strategy, and laparoscopy appears to be the ideal approach, especially insofar as it provides satisfactory postoperative comfort.
PATIENTS AND METHODS: This was a retrospective study conducted over a six-year period in the general referral hospital and the national hospital of Niamey (Niger).
RESULTS: We collected data concerning 56 cases of cholecystectomy in patients with sickle cell disease, representing of 10.3% of all cholecystectomies (gall bladder removals) performed. A majority of the patients were female (55.4%), with a mean age of 20.2 years, standard deviation of 8.8, and extreme values at 6 and 47 years. Homozygous SS forms of sickle cell disease predominated (92.9%). Nearly two-thirds of the patients (64.3%) were referred from the national sickle cell disease referral center. The main operative indication (69.6%) was symptomatic gall bladder (vesicular) lithiasis. All of the patients were anemic, with severe anemia in nearly half (44.6%). Exchange transfusion was carried out in 42.9% of the patients, and perioperative blood transfusion in 57.1%. The laparoscopic route was followed in almost all of the patients (94.6%). Mean postoperative stay in an intensive care unit was 23.5±7.2 (12-48) 48hours. The rate of postoperative complications was 23.2%, and the rate of mortality was 1.8%. As regards disease progress at one year, no vaso-occlusive crises were observed in seven eight (87.5) of the patients.
CONCLUSION: Cholecystectomy in sickle cell patients calls for a multidisciplinary strategy, and laparoscopy appears to be the ideal approach, especially insofar as it provides satisfactory postoperative comfort.