Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study.
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van Wonderen Stefan F, Raasveld Senta Jorinde, Flint Andrew W J, Schenk Jimmy, van den Oord Claudia, Reuland Merijn C, de Bruin Sanne, Bakker Jan, Cecconi Maurizio, Feldheiser Aarne, Meier Jens, Müller Marcella C A, Scheeren Thomas W L, Hamid Tarikul, Piagnerelli Michaël, Mahečić Tina Tomić, Benes Jan, Russell Lene, Aguirre-Bermeo Hernan, Triantafyllopoulou Konstantina, Chantziara Vasiliki, Gurjar Mohan, Myatra Sheila Nainan, Pota Vincenzo, Elhadi Muhammed, Gawda Ryszard, Mourisco Mafalda, Lance Marcus, Neskovic Vojislava, Podbregar Matej, Llau Juan V, Quintana-Diaz Manual, Cronhjort Maria, Pfortmueller Carmen A, Yapici Nihan, Nielsen Nathan D, Shah Akshay, de Grooth Harm-Jan, McQuilten Zoe, Vlaar Alexander P J, Aubron Cécile, InPUT Study Group
Аннотация
DESIGN: International prospective cohort study.
SETTING: Two hundred thirty-three centers in 30 countries worldwide.
PATIENTS: All patients 18 years old and older, admitted to the ICU during a single study week, selected by each site from one of the 16 predefined weeks (March 2019 to October 2022), were included.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: Of the 3643 patients, 208 (6%) received a platelet transfusion during their ICU stay and main indications consisted of active bleeding (42%, n = 187/443), prophylaxis (33%, n = 144/443) or an upcoming procedure (12%, n = 51/443). The median platelet count before transfusion was 44 × 10 9 /L (interquartile range [IQR], 20-78) with variation by indication, including a higher median of 60 × 10 9 /L (IQR 31-93) during active bleeding. A threshold for transfusion was stated in 51% ( n = 224/443) of the events, with a median threshold platelet count of 50 × 10 9 /L (IQR, 40-100). The advised threshold was not adhered to in 16% ( n = 36/224) of cases, with the majority having active bleeding as indication. Contrasts in transfusion practices were observed across different geo-economic regions. Platelet transfusions were administered to 6% ( n = 156/2520) of patients in high-income countries, 5% ( n = 52/1069) of patients in upper-middle-income countries and in none from lower-middle-income countries ( n = 0/54). Non-adherence was higher in the high-income countries (23%, n = 34/149) than upper-middle-income countries (3%, n = 2/75).
CONCLUSIONS: Platelet transfusions were administered to a small proportion of critically ill patients, and were given to treat active bleeding or as prophylaxis in the majority of cases. Occurence rate, indication and threshold adherence for platelet transfusion widely varied between geo-economic regions.