Journal of the Pediatric Infectious Diseases Society · 2020
Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Lang Peter, Eichholz Thomas, Bakchoul Tamam, Streiter Monika, Petrasch Maurice, Bösmüller Hans, Klein Reinhild, Rabsteyn Armin, Lang Anne-Marie, Adams Constantin, Klingel Karin, Gessner Michaela, Rosenberger Peter, Ruef Peter, Handgretinger Rupert
Аннотация
The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment.