Science immunology · 2021

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

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Bastard Paul, Gervais Adrian, Le Voyer Tom, Rosain Jérémie, Philippot Quentin, Manry Jérémy, Michailidis Eleftherios, Hoffmann Hans-Heinrich, Eto Shohei, Garcia-Prat Marina, Bizien Lucy, Parra-Martínez Alba, Yang Rui, Haljasmägi Liis, Migaud Mélanie, Särekannu Karita, Maslovskaja Julia, de Prost Nicolas, Tandjaoui-Lambiotte Yacine, Luyt Charles-Edouard, Amador-Borrero Blanca, Gaudet Alexandre, Poissy Julien, Morel Pascal, Richard Pascale, Cognasse Fabrice, Troya Jesus, Trouillet-Assant Sophie, Belot Alexandre, Saker Kahina, Garçon Pierre, Rivière Jacques G, Lagier Jean-Christophe, Gentile Stéphanie, Rosen Lindsey B, Shaw Elana, Morio Tomohiro, Tanaka Junko, Dalmau David, Tharaux Pierre-Louis, Sene Damien, Stepanian Alain, Megarbane Bruno, Triantafyllia Vasiliki, Fekkar Arnaud, Heath James R, Franco José Luis, Anaya Juan-Manuel, Solé-Violán Jordi, Imberti Luisa, Biondi Andrea, Bonfanti Paolo, Castagnoli Riccardo, Delmonte Ottavia M, Zhang Yu, Snow Andrew L, Holland Steven M, Biggs Catherine, Moncada-Vélez Marcela, Arias Andrés Augusto, Lorenzo Lazaro, Boucherit Soraya, Coulibaly Boubacar, Anglicheau Dany, Planas Anna M, Haerynck Filomeen, Duvlis Sotirija, Nussbaum Robert L, Ozcelik Tayfun, Keles Sevgi, Bousfiha Ahmed A, El Bakkouri Jalila, Ramirez-Santana Carolina, Paul Stéphane, Pan-Hammarström Qiang, Hammarström Lennart, Dupont Annabelle, Kurolap Alina, Metz Christine N, Aiuti Alessandro, Casari Giorgio, Lampasona Vito, Ciceri Fabio, Barreiros Lucila A, Dominguez-Garrido Elena, Vidigal Mateus, Zatz Mayana, van de Beek Diederik, Sahanic Sabina, Tancevski Ivan, Stepanovskyy Yurii, Boyarchuk Oksana, Nukui Yoko, Tsumura Miyuki, Vidaur Loreto, Tangye Stuart G, Burrel Sonia, Duffy Darragh, Quintana-Murci Lluis, Klocperk Adam, Kann Nelli Y, Shcherbina Anna, Lau Yu-Lung, Leung Daniel, Coulongeat Matthieu, Marlet Julien, Koning Rutger, Reyes Luis Felipe, Chauvineau-Grenier Angélique, Venet Fabienne, Monneret Guillaume, Nussenzweig Michel C, Arrestier Romain, Boudhabhay Idris, Baris-Feldman Hagit, Hagin David, Wauters Joost, Meyts Isabelle, Dyer Adam H, Kennelly Sean P, Bourke Nollaig M, Halwani Rabih, Sharif-Askari Narjes Saheb, Dorgham Karim, Sallette Jérome, Sedkaoui Souad Mehlal, AlKhater Suzan, Rigo-Bonnin Raúl, Morandeira Francisco, Roussel Lucie, Vinh Donald C, Ostrowski Sisse Rye, Condino-Neto Antonio, Prando Carolina, Bonradenko Anastasiia, Spaan András N, Gilardin Laurent, Fellay Jacques, Lyonnet Stanislas, Bilguvar Kaya, Lifton Richard P, Mane Shrikant, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19, Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement du Sang study group, Anderson Mark S, Boisson Bertrand, Béziat Vivien, Zhang Shen-Ying, Vandreakos Evangelos, Hermine Olivier, Pujol Aurora, Peterson Pärt, Mogensen Trine H, Rowen Lee, Mond James, Debette Stéphanie, de Lamballerie Xavier, Duval Xavier, Mentré France, Zins Marie, Soler-Palacin Pere, Colobran Roger, Gorochov Guy, Solanich Xavier, Susen Sophie, Martinez-Picado Javier, Raoult Didier, Vasse Marc, Gregersen Peter K, Piemonti Lorenzo, Rodríguez-Gallego Carlos, Notarangelo Luigi D, Su Helen C, Kisand Kai, Okada Satoshi, Puel Anne, Jouanguy Emmanuelle, Rice Charles M, Tiberghien Pierre, Zhang Qian, Cobat Aurélie, Abel Laurent, Casanova Jean-Laurent

Аннотация

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.

Предметные рубрики MeSH

Adolescent Adult Aged Aged, 80 and over Antibodies, Neutralizing Autoantibodies COVID-19 Case-Control Studies Child Child, Preschool Critical Illness Humans Immunoglobulin G Infant Infant, Newborn Interferon Type I Interferon-alpha Middle Aged Young Adult

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH