Journal of medical virology · 2005
Molecular evidence of HTLV-1 intrafamilial transmission in a non-endemic area in Argentina.
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Gastaldello R, Otsuki K, Barbas M G, Vicente A C P, Gallego S
Аннотация
In the North of Argentina, an endemic area for HTLV-1, intrafamilial transmission of this virus has been observed. The HTLV-1 status in 13 family members of a seropositive blood donor from the central region of Argentina (non-endemic area) was investigated. According to serological and molecular assays, four members of this family (the blood donor, the husband, a son, and a daughter-in-law) proved to be HTLV-1 positive. LTR, tax, and env sequences from the provirus infecting the family members were identical. This strongly suggests the intrafamilial transmission of the virus. This study demonstrated intrafamilial transmission of HTLV-1 in a non-endemic area of Argentina.
Предметные рубрики MeSH
AdultAgedAntibodies, ViralArgentinaDNA, ViralFamily HealthFemaleFluorescent Antibody Technique, IndirectGene Products, taxGenes, envGenes, pXHTLV-I InfectionsHuman T-lymphotropic virus 1HumansImmunoblottingMaleMiddle AgedMolecular Sequence DataPedigreePhylogenyProvirusesSequence Analysis, DNATerminal Repeat Sequences