Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Dokubo Emily Kainne, Wendland Annika, Mate Suzanne E, Ladner Jason T, Hamblion Esther L, Raftery Philomena, Blackley David J, Laney A Scott, Mahmoud Nuha, Wayne-Davies Gloria, Hensley Lisa, Stavale Eric, Fakoli Lawrence, Gregory Christopher, Chen Tai-Ho, Koryon Augustine, Roth Allen Denise, Mann Jennifer, Hickey Andrew, Saindon John, Badini Mehboob, Baller April, Clement Peter, Bolay Fatorma, Wapoe Yatta, Wiley Michael R, Logue James, Dighero-Kemp Bonnie, Higgs Elizabeth, Gasasira Alex, Williams Desmond E, Dahn Bernice, Kateh Francis, Nyenswah Tolbert, Palacios Gustavo, Fallah Mosoka P
Аннотация
METHODS: Case investigations were done to ascertain previous contact with cases of Ebola virus disease or infection with Ebola virus. Molecular investigations on blood samples explored a potential linkage between Ebola virus isolated from cases in this November, 2015, cluster and epidemiologically linked cases from the 2014-15 west African outbreak, according to the national case database.
FINDINGS: The cluster investigated was the family of the index case (mother, father, three siblings). Ebola virus genomes assembled from two cases in the November, 2015, cluster, and an epidemiologically linked Ebola virus disease case in July, 2014, were phylogenetically related within the LB5 sublineage that circulated in Liberia starting around August, 2014. Partial genomes from two additional individuals, one from each cluster, were also consistent with placement in the LB5 sublineage. Sequencing data indicate infection with a lineage of the virus from a former transmission chain in the country. Based on serology and epidemiological and genomic data, the most plausible scenario is that a female case in the November, 2015, cluster survived Ebola virus disease in 2014, had viral persistence or recurrent disease, and transmitted the virus to three family members a year later.
INTERPRETATION: Investigation of the source of infection for the November, 2015, cluster provides evidence of Ebola virus persistence and highlights the risk for outbreaks after interruption of active transmission. These findings underscore the need for focused prevention efforts among survivors and sustained capacity to rapidly detect and respond to new Ebola virus disease cases to prevent recurrence of a widespread outbreak.
FUNDING: US Centers for Disease Control and Prevention, Defense Threat Reduction Agency, and WHO.