Magnetic resonance in medicine · 2026
Short Echo-Time Spiral MRSI Versus Single-Voxel Spectroscopy in the Human Brain at 3 Tesla With Semi-LASER Localization.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Park Young Woo, Adanyeguh Isaac M, Henry Pierre-Gilles, Deelchand Dinesh K
Аннотация
PURPOSE: Magnetic resonance spectroscopy techniques are widely used to non-invasively study brain metabolism. Despite advances in magnetic resonance spectroscopic imaging (MRSI), there is a notable absence of research on comparing fast non-Cartesian MRSI with single-voxel spectroscopy (SVS), limiting our understanding of its performance and applicability. In this study, we compared the spectral quality and metabolite concentrations obtained using short-TE 2D spiral MRSI and SVS in the same region in the human brain at 3T.
METHODS: Five healthy subjects were scanned at 3T. 2D spiral MRSI data were acquired in a transverse slice through the posterior cingulate cortex (PCC), while the SVS volume was placed within the PCC region. Both techniques employed the standardized semi-LASER sequence for localization. All data were processed in Matlab and fitted with LCModel.
RESULTS: Visual inspection suggested comparable overall spectral quality between the two acquisitions. Quantitatively, however, the PCC voxel measured with MRSI exhibited lower signal-to-noise ratio (SNR) compared to SVS at identical scan times, when the SVS voxel matched the effective MRSI voxel. Consistent with lower SNR, metabolite quantification showed higher Cramer-Rao lower bounds with MRSI. In addition, concentrations of glutamate and glutamate plus glutamine were lower with MRSI.
CONCLUSION: Our findings demonstrate that the quality of semi-LASER localized short-TE spiral MRSI spectra is very comparable to that of semi-LASER localized SVS spectra. Small metabolic-specific concentration differences may be due to different WM/GM tissue weighting within the voxel (slice selection profile in SVS vs. point-spread function in MRSI) and different SNR between the two techniques.
METHODS: Five healthy subjects were scanned at 3T. 2D spiral MRSI data were acquired in a transverse slice through the posterior cingulate cortex (PCC), while the SVS volume was placed within the PCC region. Both techniques employed the standardized semi-LASER sequence for localization. All data were processed in Matlab and fitted with LCModel.
RESULTS: Visual inspection suggested comparable overall spectral quality between the two acquisitions. Quantitatively, however, the PCC voxel measured with MRSI exhibited lower signal-to-noise ratio (SNR) compared to SVS at identical scan times, when the SVS voxel matched the effective MRSI voxel. Consistent with lower SNR, metabolite quantification showed higher Cramer-Rao lower bounds with MRSI. In addition, concentrations of glutamate and glutamate plus glutamine were lower with MRSI.
CONCLUSION: Our findings demonstrate that the quality of semi-LASER localized short-TE spiral MRSI spectra is very comparable to that of semi-LASER localized SVS spectra. Small metabolic-specific concentration differences may be due to different WM/GM tissue weighting within the voxel (slice selection profile in SVS vs. point-spread function in MRSI) and different SNR between the two techniques.