Медицинская библиотека · The Journal of infectious diseases · 2016

Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.

Kerber Romy, Krumkamp Ralf, Diallo Boubacar, Jaeger Anna, Rudolf Martin, Lanini Simone, Bore Joseph Akoi, Koundouno Fara Raymond, Becker-Ziaja Beate, Fleischmann Erna, Stoecker Kilian, Meschi Silvia, Mély Stéphane, Newman Edmund N C, Carletti Fabrizio, Portmann Jasmine, Korva Misa, Wolff Svenja, Molkenthin Peter, Kis Zoltan, Kelterbaum Anne, Bocquin Anne, Strecker Thomas, Fizet Alexandra, Castilletti Concetta, Schudt Gordian, Ottowell Lisa, Kurth Andreas, Atkinson Barry, Badusche Marlis, Cannas Angela, Pallasch Elisa, Bosworth Andrew, Yue Constanze, Pályi Bernadett, Ellerbrok Heinz, Kohl Claudia, Oestereich Lisa, Logue Christopher H, Lüdtke Anja, Richter Martin, Ngabo Didier, Borremans Benny, Becker Dirk, Gryseels Sophie, Abdellati Saïd, Vermoesen Tine, Kuisma Eeva, Kraus Annette, Liedigk Britta, Maes Piet, Thom Ruth, Duraffour Sophie, Diederich Sandra, Hinzmann Julia, Afrough Babak, Repits Johanna, Mertens Marc, Vitoriano Inês, Bah Amadou, Sachse Andreas, Boettcher Jan Peter, Wurr Stephanie, Bockholt Sabrina, Nitsche Andreas, Županc Tatjana Avšič, Strasser Marc, Ippolito Giuseppe, Becker Stephan, Raoul Herve, Carroll Miles W, De Clerck Hilde, Van Herp Michel, Sprecher Armand, Koivogui Lamine, Magassouba N'Faly, Keïta Sakoba, Drury Patrick, Gurry Cèline, Formenty Pierre, May Jürgen, Gabriel Martin, Wölfel Roman, Günther Stephan, Di Caro Antonino

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Аннотация

BACKGROUND

A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015.

METHODS

The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively.

RESULTS

The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virus-malaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 10-19 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 5-14 years, malaria parasite coinfection were independent determinants of a poor EVD outcome.

CONCLUSIONS

Virus load, age, and malaria parasite coinfection play a role in the outcome of EVD.

Для цитирования: Kerber Romy, Krumkamp Ralf, Diallo Boubacar, Jaeger Anna, Rudolf Martin, Lanini Simone, Bore Joseph Akoi, Koundouno Fara Raymond, Becker-Ziaja Beate, Fleischmann Erna, Stoecker Kilian, Meschi Silvia, Mély Stéphane, Newman Edmund N C, Carletti Fabrizio, Portmann Jasmine, Korva Misa, Wolff Svenja, Molkenthin Peter, Kis Zoltan, Kelterbaum Anne, Bocquin Anne, Strecker Thomas, Fizet Alexandra, Castilletti Concetta, Schudt Gordian, Ottowell Lisa, Kurth Andreas, Atkinson Barry, Badusche Marlis, Cannas Angela, Pallasch Elisa, Bosworth Andrew, Yue Constanze, Pályi Bernadett, Ellerbrok Heinz, Kohl Claudia, Oestereich Lisa, Logue Christopher H, Lüdtke Anja, Richter Martin, Ngabo Didier, Borremans Benny, Becker Dirk, Gryseels Sophie, Abdellati Saïd, Vermoesen Tine, Kuisma Eeva, Kraus Annette, Liedigk Britta, Maes Piet, Thom Ruth, Duraffour Sophie, Diederich Sandra, Hinzmann Julia, Afrough Babak, Repits Johanna, Mertens Marc, Vitoriano Inês, Bah Amadou, Sachse Andreas, Boettcher Jan Peter, Wurr Stephanie, Bockholt Sabrina, Nitsche Andreas, Županc Tatjana Avšič, Strasser Marc, Ippolito Giuseppe, Becker Stephan, Raoul Herve, Carroll Miles W, De Clerck Hilde, Van Herp Michel, Sprecher Armand, Koivogui Lamine, Magassouba N'Faly, Keïta Sakoba, Drury Patrick, Gurry Cèline, Formenty Pierre, May Jürgen, Gabriel Martin, Wölfel Roman, Günther Stephan, Di Caro Antonino. Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.. The Journal of infectious diseases. 2016. DOI: 10.1093/infdis/jiw269.

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