Endocrine, metabolic & immune disorders drug targets · 2026
Assessment of Exercise-Stimulated Irisin in Kidney Disease: A Systematic Review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Shintaku Enzo, Vantini Davi, Ting João Gabriel Bicudo, Zuniga Rubén David Dos Reis, Luciano da Veiga Glaucia, Alves Beatriz da Costa Aguiar, Encinas Jéssica Freitas, Fonseca Fernando Luiz Affonso
Аннотация
INTRODUCTION: Irisin is a hormone synthesized by skeletal muscle cells in response to physical exercise. It has been linked to various health benefits, including improved insulin sensitivity, fat burning, reduced inflammation, and potential protection against metabolic diseases, such as obesity and type 2 diabetes. This review explores the role of irisin, stimulated by physical exercise, in kidney diseases.
METHODS: A comprehensive review was conducted using SciELO, PubMed, Scopus, Web of Science, and EMBASE. Five articles were selected based on pre-established eligibility criteria. These studies used animal experiments, assessing irisin predominantly through Western blotting or ELISA, with aerobic exercise protocols, mainly treadmill running.
RESULTS: The results consistently showed an increase in irisin levels in response to physical exercise in animal models with kidney diseases.
DISCUSSION: Aerobic exercise increased plasma irisin expression, with better outcomes observed with low to medium-intensity training. Irisin demonstrated therapeutic potential by reducing renal cysts, inhibiting epithelial-mesenchymal transition, decreasing markers of diabetic nephropathy, and restoring autophagy in podocytes. Additionally, it activated the AMPK-Sirt1-PGC-1α pathway, suggesting antioxidant and antiapoptotic effects.
CONCLUSION: The studies reviewed suggested that aerobic exercise increased irisin levels in animal models of kidney diseases, showing potential therapeutic effects for renal health.
METHODS: A comprehensive review was conducted using SciELO, PubMed, Scopus, Web of Science, and EMBASE. Five articles were selected based on pre-established eligibility criteria. These studies used animal experiments, assessing irisin predominantly through Western blotting or ELISA, with aerobic exercise protocols, mainly treadmill running.
RESULTS: The results consistently showed an increase in irisin levels in response to physical exercise in animal models with kidney diseases.
DISCUSSION: Aerobic exercise increased plasma irisin expression, with better outcomes observed with low to medium-intensity training. Irisin demonstrated therapeutic potential by reducing renal cysts, inhibiting epithelial-mesenchymal transition, decreasing markers of diabetic nephropathy, and restoring autophagy in podocytes. Additionally, it activated the AMPK-Sirt1-PGC-1α pathway, suggesting antioxidant and antiapoptotic effects.
CONCLUSION: The studies reviewed suggested that aerobic exercise increased irisin levels in animal models of kidney diseases, showing potential therapeutic effects for renal health.