Journal of public health management and practice : JPHMP · 2012
Use of tuberculosis genotyping for postoutbreak monitoring.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Miramontes Roque, Winston Carla A, Haddad Maryam B, Moonan Patrick K
Аннотация
CONTEXT: Review of routinely collected tuberculosis genotyping results following a known outbreak is a potential mechanism to examine the effectiveness of outbreak control measures.
OBJECTIVE: To assess differences in characteristics between outbreak and postoutbreak tuberculosis cases.
DESIGN: Retrospective.
SETTING: United States.
PARTICIPANTS: All tuberculosis cases identified as a result of >5-person outbreaks investigated by the Centers for Disease Control and Prevention during 2003 to 2007 (original outbreak cases), and subsequent culture-positive tuberculosis cases with matching Mycobacterium tuberculosis genotypes reported in the same county during 2004 to 2008 (postoutbreak cases).
MAIN OUTCOME MEASURE: Proportion of demographic, social, and clinical characteristics of tuberculosis outbreak cases compared to postoutbreak cases. SECONDARY: Proportion of demographic, social, and clinical characteristics of epidemiologically linked versus nonlinked cases.
RESULTS: Six outbreaks with 111 outbreak cases and 110 postoutbreak cases were identified. Differences between outbreak and postoutbreak cases were gender (69% vs 85% male; P < .01), birth origin (3% vs 11% foreign-born; P = .02), disease severity (48% vs 62% sputum smear-positive; P = .04), homelessness (38% vs 51%; P = .05), and injection drug use (4% vs 11%; P = .04). For 5 of the 6 outbreaks, the status of epidemiologic relationships among postoutbreak cases was available (n = 89). The postoutbreak cases with a known epidemiologic link to the original outbreak were in younger persons (aged 39 vs 47 years; P < .01), and a larger proportion reported injection drug use (18% vs 4%; P = .04) or noninjection drug use (44% vs 18%; P < .01) than those without a reported link.
CONCLUSIONS: Health jurisdictions can utilize genotyping data to monitor and define the characteristics of postoutbreak cases related to the original outbreak.
OBJECTIVE: To assess differences in characteristics between outbreak and postoutbreak tuberculosis cases.
DESIGN: Retrospective.
SETTING: United States.
PARTICIPANTS: All tuberculosis cases identified as a result of >5-person outbreaks investigated by the Centers for Disease Control and Prevention during 2003 to 2007 (original outbreak cases), and subsequent culture-positive tuberculosis cases with matching Mycobacterium tuberculosis genotypes reported in the same county during 2004 to 2008 (postoutbreak cases).
MAIN OUTCOME MEASURE: Proportion of demographic, social, and clinical characteristics of tuberculosis outbreak cases compared to postoutbreak cases. SECONDARY: Proportion of demographic, social, and clinical characteristics of epidemiologically linked versus nonlinked cases.
RESULTS: Six outbreaks with 111 outbreak cases and 110 postoutbreak cases were identified. Differences between outbreak and postoutbreak cases were gender (69% vs 85% male; P < .01), birth origin (3% vs 11% foreign-born; P = .02), disease severity (48% vs 62% sputum smear-positive; P = .04), homelessness (38% vs 51%; P = .05), and injection drug use (4% vs 11%; P = .04). For 5 of the 6 outbreaks, the status of epidemiologic relationships among postoutbreak cases was available (n = 89). The postoutbreak cases with a known epidemiologic link to the original outbreak were in younger persons (aged 39 vs 47 years; P < .01), and a larger proportion reported injection drug use (18% vs 4%; P = .04) or noninjection drug use (44% vs 18%; P < .01) than those without a reported link.
CONCLUSIONS: Health jurisdictions can utilize genotyping data to monitor and define the characteristics of postoutbreak cases related to the original outbreak.
Предметные рубрики MeSH
AdolescentAdultAgedCenters for Disease Control and Prevention, U.S.ChildChild, PreschoolCulture TechniquesDisease OutbreaksEmigration and ImmigrationFemaleGenotyping TechniquesIll-Housed PersonsHumansInfantInfant, NewbornInfection ControlMaleMiddle AgedMolecular EpidemiologyMycobacterium tuberculosisPolymorphism, Restriction Fragment LengthPopulation SurveillancePrevalencePrisonersRetrospective StudiesSensitivity and SpecificitySex DistributionSputumSubstance Abuse, IntravenousTuberculosis, PulmonaryUnited States