[Current clinical manifestations of tuberculosis].

Tuberculosis is an enormously serious and growing global disease that is becoming increasingly concentrated in the so-called "developing" nations of the world, where the epidemic is fuelled by the rapid expansion of the population, the presence of extreme poverty, and the coexistence of HIV infection. Most persons who become infected with M. tuberculosis do not develop the disease tuberculosis. In those who do, two types are recognised: 1) early progression of the primary pulmonary lesion or its lymph node component, or a complication from hematogenous dissemination, and 2) late reactivation of one or more previously latent sites, of which upper lobe pulmonary disease is the most common; extrapulmonary disease may also occur. Progressive immunosuppression from HIV infection exaggerates and accelerates the evolution of virtually all aspects of tuberculosis.