Infection · 2025
Global, regional, and national burden of lower respiratory infections and chronic obstructive pulmonary disease, 1990-2021: a systematic analysis from the global burden of disease study 2021.
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Wang Yi-Yuan, Wang Jing, Lu Zhang-Wei, Zhou Qian-Qian, Cao Yang-Guang, Du Yu-Jie, Jin Xue, Li Bao-Zhu
Аннотация
PURPOSE: This study evaluates the global burden of lower respiratory infections (LRIs) and chronic obstructive pulmonary disease (COPD), focusing on their combined impact across age groups and regions.
METHODS: Data from 204 countries were analyzed using spatiotemporal Gaussian process regression to estimate LRI and COPD incidence, prevalence, and disability-adjusted life years (DALYs). Age-standardized ratios (ASR) and the Socio-Demographic Index (SDI) were used to compare disease burdens, with trends assessed via linear regression and restricted cubic spline models.
RESULTS: In 2021, COPD and LRI caused 360 million cases and 5.9 million deaths, with the highest burden in low-SDI regions. COPD remained the fourth leading cause of death, while LRI dropped to seventh.
CONCLUSION: The bidirectional link between LRI and COPD exacerbates disease progression, disproportionately affecting low-income regions and aging populations. Addressing disparities in healthcare access, improving vaccines, and strengthening public health infrastructure are critical to reducing the global burden of these diseases.
METHODS: Data from 204 countries were analyzed using spatiotemporal Gaussian process regression to estimate LRI and COPD incidence, prevalence, and disability-adjusted life years (DALYs). Age-standardized ratios (ASR) and the Socio-Demographic Index (SDI) were used to compare disease burdens, with trends assessed via linear regression and restricted cubic spline models.
RESULTS: In 2021, COPD and LRI caused 360 million cases and 5.9 million deaths, with the highest burden in low-SDI regions. COPD remained the fourth leading cause of death, while LRI dropped to seventh.
CONCLUSION: The bidirectional link between LRI and COPD exacerbates disease progression, disproportionately affecting low-income regions and aging populations. Addressing disparities in healthcare access, improving vaccines, and strengthening public health infrastructure are critical to reducing the global burden of these diseases.