Pediatric Cutaneous Graft-Versus-Host Disease: Clinical Presentations, Management, and Emerging Therapies.

Cutaneous graft-versus-host disease (GVHD) is a significant complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). This review offers a clinically focused update on the diagnosis and management of acute and chronic cutaneous GVHD in pediatric patients. We highlight recent advances in clinical classification systems and therapeutic options, including newly FDA-approved treatments for steroid-refractory disease. Given the risk of long-term morbidity, multidisciplinary care and consistent dermatologic follow-up are essential. Future research should focus on pediatric-specific diagnosis and treatment to address age-specific presentation, drug response, and safety, as well as the potential of less immunosuppressive therapies for select cutaneous GVHD phenotypes.