Current opinion in organ transplantation · 2025
Combined molecular mismatch scores for immunologic risk stratification in pediatric heart transplantation.
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Ellison Mitchell A, Xu Qingyong, Zeevi Adriana
Аннотация
PURPOSE OF REVIEW: This article will review the use of HLA molecular mismatch algorithms to predict the risk of de-novo DSA and rejection in pediatric heart transplant recipients. Here, we will focus on results obtained using the combined algorithm approach pairing HLAMatchmaker or HLA-EMMA with PIRCHE-II.
RECENT FINDINGS: The combined algorithm approach was recently used to assess risk of de-novo DSA and rejection in a pediatric heart transplant cohort from Clinical Trials in Organ Transplant in Children 04/09. This approach to analyzing HLA molecular mismatch data allowed for a more granular assessment of de-novo DSA and rejection risk than any individual algorithm.
SUMMARY: Advances in HLA molecular mismatch methods may enable personalized immunosuppression management that improves outcomes of pediatric heart transplant recipients.
RECENT FINDINGS: The combined algorithm approach was recently used to assess risk of de-novo DSA and rejection in a pediatric heart transplant cohort from Clinical Trials in Organ Transplant in Children 04/09. This approach to analyzing HLA molecular mismatch data allowed for a more granular assessment of de-novo DSA and rejection risk than any individual algorithm.
SUMMARY: Advances in HLA molecular mismatch methods may enable personalized immunosuppression management that improves outcomes of pediatric heart transplant recipients.