Pregnancy outcomes in Greek women with inflammatory bowel disease: a longitudinal national retrospective study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Papathanasiou Evgenia, Kokkotis Georgios, Axiaris Georgios, Bellou Georgia, Chalakatevaki Konstantina, Christidou Angeliki, Christodoulou Dimitrios K, Foteinogiannopoulou Kalliopi, Gatopoulou Anthia, Giouleme Olga, Gkoumas Konstantinos, Κalogirou Maria, Karatzas Pantelis, Κarmiris Konstantinos, Κatsanos Konstantinos, Κourikou Anastasia, Κoutroubakis Ioannis E, Liatsos Christos, Mantzaris Gerassimos J, Μathou Nicoletta, Michalopoulos George, Μantaka Aikaterini, Nikolaou Penelope, Oikonomou Michael, Papatheodoridis George, Polymeros Dimitrios, Skouloudis Epameinondas, Soufleris Konstantinos, Stergiou Evdoxia, Theodoulou Aggelos, Theodoropoulou Angeliki, Theoxaris Georgios, Tsafaraki Styliani, Tsiolakidou Georgia, Tsironi Eftychia, Tzouvala Maria, Viazis Nikos, Michopoulos Spyridon, Bamias Giorgos, Zampeli Evanthia
Аннотация
METHODS: Α national retrospective study of pregnancies in women with IBD between 2010 and 2020 was carried out in 22 IBD reference centers in Greece.
RESULTS IN TOTAL: 223 pregnancies in 175 IBD patients [122 Crohn's disease (CD)] were included. Mean age at diagnosis was 26 years (12-44) with a mean duration of 7.4 (0-23). Pregnancy as a result of IVF occurred in 15 cases (6.7%). At the beginning of gestation, 165 patients (74%) were under treatment: 48 (29%) with anti-tumor necrosis factor alpha agents, 43 (26%) with azathioprine, 101 (61%) with 5-aminosalicylates, and 12 (7%) with steroids. Forty-nine cases (22%) of IBD flares were recorded: Two-thirds ( n = 30) were in clinical remission at the onset of pregnancy, whereas treatment with corticosteroids was required in 22 (45%). Patients with ulcerative colitis were at greater risk for flare compared to those with CD ( P < 0.001). All but two pregnancies (99.1%) resulted in an uncomplicated delivery. In 147 cases (67.1%), c-section was performed. Two late fetal deaths (0.9%) were reported, both in patients with persistently active disease. After delivery, 75 patients (34%) presented with a disease flare, associated with active disease at the beginning of pregnancy ( P < 0.001).
CONCLUSION: The majority of Greek patients with IBD have a favorable pregnancy outcome. Active inflammation during gestation and a diagnosis of ulcerative colitis are negatively associated with pregnancy outcomes.