Journal of psychiatric research · 2023
Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: A systematic review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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González-Castro Thelma Beatriz, Juárez-Rojop Isela Esther, Tovilla-Zárate Carlos Alfonso, Ovando-Ricárdez José Antonio, Hernández-Díaz Yazmin, López-Narváez María Lilia, Genis-Mendoza Alma Delia, Rodríguez-Pérez Candelario
Аннотация
Suicide behavior (SB) emerge from complex interactions among traumatic events and multiple genetic factors. We conducted the first systematic review to assess the evidence of a link among trauma exposure, HPA-axis genes, and SB. A systematic search of PubMed, EBSCO, Science Direct, PsychInfo, and Scopus databases on gene-environment interaction, and susceptibility to SB was carried out until February 2022. Our study was prospectively registered in PROSPERO (CRD42022316141). A total of 13 epidemiological studies (11,756 subjects) were included: eight studies focused on traumatic experiences in the childhood and five studies on lifetime trauma exposure. All studies reported a positive association between the trauma exposure with SB. Gene-environment interaction was reported for CRHR1 (n = 6), CRHR2 (n = 2), FKBP5 (n = 2), and CRHBP (n = 1), however, for CRH, NR3C1, MC2R, and POMC genes no found gene-environment effects on SB. Trauma exposure could be one mechanism that links HPA-axis genes activity with the development of SB.