Медицинская библиотека · The American journal of psychiatry · 2019

Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.

Hoogman Martine, Muetzel Ryan, Guimaraes Joao P, Shumskaya Elena, Mennes Maarten, Zwiers Marcel P, Jahanshad Neda, Sudre Gustavo, Wolfers Thomas, Earl Eric A, Soliva Vila Juan Carlos, Vives-Gilabert Yolanda, Khadka Sabin, Novotny Stephanie E, Hartman Catharina A, Heslenfeld Dirk J, Schweren Lizanne J S, Ambrosino Sara, Oranje Bob, de Zeeuw Patrick, Chaim-Avancini Tiffany M, Rosa Pedro G P, Zanetti Marcus V, Malpas Charles B, Kohls Gregor, von Polier Georg G, Seitz Jochen, Biederman Joseph, Doyle Alysa E, Dale Anders M, van Erp Theo G M, Epstein Jeffery N, Jernigan Terry L, Baur-Streubel Ramona, Ziegler Georg C, Zierhut Kathrin C, Schrantee Anouk, Høvik Marie F, Lundervold Astri J, Kelly Clare, McCarthy Hazel, Skokauskas Norbert, O'Gorman Tuura Ruth L, Calvo Anna, Lera-Miguel Sara, Nicolau Rosa, Chantiluke Kaylita C, Christakou Anastasia, Vance Alasdair, Cercignani Mara, Gabel Matt C, Asherson Philip, Baumeister Sarah, Brandeis Daniel, Hohmann Sarah, Bramati Ivanei E, Tovar-Moll Fernanda, Fallgatter Andreas J, Kardatzki Bernd, Schwarz Lena, Anikin Anatoly, Baranov Alexandr, Gogberashvili Tinatin, Kapilushniy Dmitry, Solovieva Anastasia, El Marroun Hanan, White Tonya, Karkashadze Georgii, Namazova-Baranova Leyla, Ethofer Thomas, Mattos Paulo, Banaschewski Tobias, Coghill David, Plessen Kerstin J, Kuntsi Jonna, Mehta Mitul A, Paloyelis Yannis, Harrison Neil A, Bellgrove Mark A, Silk Tim J, Cubillo Ana I, Rubia Katya, Lazaro Luisa, Brem Silvia, Walitza Susanne, Frodl Thomas, Zentis Mariam, Castellanos Francisco X, Yoncheva Yuliya N, Haavik Jan, Reneman Liesbeth, Conzelmann Annette, Lesch Klaus-Peter, Pauli Paul, Reif Andreas, Tamm Leanne, Konrad Kerstin, Oberwelland Weiss Eileen, Busatto Geraldo F, Louza Mario R, Durston Sarah, Hoekstra Pieter J, Oosterlaan Jaap, Stevens Michael C, Ramos-Quiroga J Antoni, Vilarroya Oscar, Fair Damien A, Nigg Joel T, Thompson Paul M, Buitelaar Jan K, Faraone Stephen V, Shaw Philip, Tiemeier Henning, Bralten Janita, Franke Barbara

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Аннотация

OBJECTIVE

Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies.

METHODS

Cortical thickness and surface area (based on the Desikan-Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506) were compared. Associations of the attention scale from the Child Behavior Checklist with cortical measures were determined in a pediatric population sample (Generation-R, N=2,707).

RESULTS

In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen's d=-0.21). Fusiform gyrus and temporal pole cortical thickness was also lower in children with ADHD. Neither surface area nor thickness differences were found in the adolescent or adult groups. Familial effects were seen for surface area in several regions. In an overlapping set of regions, surface area, but not thickness, was associated with attention problems in the Generation-R sample.

CONCLUSIONS

Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis.

Для цитирования: Hoogman Martine, Muetzel Ryan, Guimaraes Joao P, Shumskaya Elena, Mennes Maarten, Zwiers Marcel P, Jahanshad Neda, Sudre Gustavo, Wolfers Thomas, Earl Eric A, Soliva Vila Juan Carlos, Vives-Gilabert Yolanda, Khadka Sabin, Novotny Stephanie E, Hartman Catharina A, Heslenfeld Dirk J, Schweren Lizanne J S, Ambrosino Sara, Oranje Bob, de Zeeuw Patrick, Chaim-Avancini Tiffany M, Rosa Pedro G P, Zanetti Marcus V, Malpas Charles B, Kohls Gregor, von Polier Georg G, Seitz Jochen, Biederman Joseph, Doyle Alysa E, Dale Anders M, van Erp Theo G M, Epstein Jeffery N, Jernigan Terry L, Baur-Streubel Ramona, Ziegler Georg C, Zierhut Kathrin C, Schrantee Anouk, Høvik Marie F, Lundervold Astri J, Kelly Clare, McCarthy Hazel, Skokauskas Norbert, O'Gorman Tuura Ruth L, Calvo Anna, Lera-Miguel Sara, Nicolau Rosa, Chantiluke Kaylita C, Christakou Anastasia, Vance Alasdair, Cercignani Mara, Gabel Matt C, Asherson Philip, Baumeister Sarah, Brandeis Daniel, Hohmann Sarah, Bramati Ivanei E, Tovar-Moll Fernanda, Fallgatter Andreas J, Kardatzki Bernd, Schwarz Lena, Anikin Anatoly, Baranov Alexandr, Gogberashvili Tinatin, Kapilushniy Dmitry, Solovieva Anastasia, El Marroun Hanan, White Tonya, Karkashadze Georgii, Namazova-Baranova Leyla, Ethofer Thomas, Mattos Paulo, Banaschewski Tobias, Coghill David, Plessen Kerstin J, Kuntsi Jonna, Mehta Mitul A, Paloyelis Yannis, Harrison Neil A, Bellgrove Mark A, Silk Tim J, Cubillo Ana I, Rubia Katya, Lazaro Luisa, Brem Silvia, Walitza Susanne, Frodl Thomas, Zentis Mariam, Castellanos Francisco X, Yoncheva Yuliya N, Haavik Jan, Reneman Liesbeth, Conzelmann Annette, Lesch Klaus-Peter, Pauli Paul, Reif Andreas, Tamm Leanne, Konrad Kerstin, Oberwelland Weiss Eileen, Busatto Geraldo F, Louza Mario R, Durston Sarah, Hoekstra Pieter J, Oosterlaan Jaap, Stevens Michael C, Ramos-Quiroga J Antoni, Vilarroya Oscar, Fair Damien A, Nigg Joel T, Thompson Paul M, Buitelaar Jan K, Faraone Stephen V, Shaw Philip, Tiemeier Henning, Bralten Janita, Franke Barbara. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.. The American journal of psychiatry. 2019. DOI: 10.1176/appi.ajp.2019.18091033.

Предметные рубрики MeSH

Adolescent Adult Age Factors Attention Deficit Disorder with Hyperactivity Case-Control Studies Cerebral Cortex Child Child, Preschool Female Humans Magnetic Resonance Imaging Male Middle Aged Neuroimaging Psychiatric Status Rating Scales Sex Factors Young Adult

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