Antihemostatic and antithrombotic effects of XC386.

XC386 prolonged the tail bleeding time in the conscious mice. This effect was dose-dependent and persisted for at least six hours after the oral administration. XC386 was effective in preventing ADP-induced acute pulmonary thromboembolic death in mice at dose of 100 mg/kg. Aspirin and indomethacin had no effect on this model. XC386 also reduced the mortality rate in collagen- induced thromboembolic death at the same dose as aspirin and indomethacin (200 mg/kg). All three drugs caused no significant protection in endotoxin shock. XC386 was found to suppress collagen-induced platelet aggregation, but did not affect blood coagulation. In conclusion, XC386 was proved to be as effective as aspirin and indomethacin in preventing the death of acute pulmonary thromboembolism.