Antithrombotic drugs and experimental thrombosis.

A series of standardized thrombosis models in rats has been used to survey some most important groups of antithrombotics. Most results confirmed the previous clinical and experimental experience but some of them bring new evidence. Very effective from this aspect appear to be dipyridamole, low-molecular weight dextran and flavonoids. Particularly favourable was the effect of the combination of flavonoids and acetylsalicylic acid which eliminates some untoward effects of the latter drug.