Cell research · 2025
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fu Wei, Lai Yuanting, Li Kexin, Yang Yue, Guo Xiao, Gong Qifan, Zhou Xiaofeng, Zhou Liying, Liu Cenxi, Zhang Zhi, So Jisun, Zhang Yufeng, Huang Lin, Lu Guangxing, Yi Chuanyou, Wang Qichu, Fan Chenyu, Liu Chao, Wang Jiaxing, Yu Haiyi, Zhao Yimin, Huang Tao, Roh Hyun Cheol, Liu Tiemin, Tang Huiru, Qi Jianping, Xu Ming, Zheng Yan, Huang He, Li Jin
Аннотация
Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2. In the current study, we found that the depletion of Ntsr2 in white adipocytes upregulated food intake, while the local treatment of NTS suppressed food intake. Our mechanistic study revealed that suppression of NTS-NTSR2 signaling enhanced the phosphorylation of ceramide synthetase 2, increased the abundance of its products ceramides C20-C24, and downregulated the production of GDF15 in white adipose tissues, which was responsible for the elevation of food intake. We discovered a potential causal and positive correlation between serum C20-C24 ceramide levels and human food intake in four populations with different ages and ethnic backgrounds. Together, our study shows that NTS-NTSR2 signaling in white adipocytes can regulate food intake via its direct control of lipid metabolism and production of GDF15. The ceramides C20-C24 are key factors regulating food intake in mammals.