Therapeutic delivery · 2024
Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ndlovu Sindi P, M Motaung Shirley C, Adeyemi Samson A, Ubanako Philemon, Ngema Lindokuhle M, Fonkui Thierry Youmbi, Ndinteh Derek Tantoh, Kumar Pradeep, Choonara Yahya E, Aderibigbe Blessing A
Аннотация
Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques.Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study.Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.