Casopis lekaru ceskych · 1998
[Hypertonic-hyperoncotic volume replacement with Tensitone].
Клиническое исследованиеКонтролируемое клиническое исследованиеСтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Vokrouhlický L, Soucek R
Аннотация
BACKGROUND: The use of hypertonic-hyperoncotic solutions (HHS) is a modern method of volume restoration in hypovolaemias of different etiology. The objective of the present work was to evaluate the effectiveness and safety of the hypertonic-hyperoncotic plasma expander Tensitone (7.5% NaCl in 6% dextran 70, Infusia a.s., CR) in patients with a massive acute blood loss.
METHODS AND RESULTS: In a multicentre clinical study the authors investigated the effect of a rapid infusion of a small volume of tensitone (4 ml/kg) on the restoration of basic haemodynamic parameters, diuresis and the general condition of 81 patients with massive traumatic or peroperative haemorrhage. As compared with the effect of standard volume expanders (N = 34), Tensitone had a markedly more rapid and more pronounced effect on the normalization of the blood pressure (p < 0.01), heart rate (p < 0.05), central venous pressure and diuresis (p < 0.01). The haemodynamic effects of Tensitone are almost immediate (rise of blood pressure within 10 minutes) while they are at the same time sufficiently protracted (for at least 2 hours). The tolerance and safety of treatment were very good, more serious undesirable effects (thrombophlebitis) were recorded only in 3.6% of the patients.
CONCLUSIONS: Tensitone is an effective and safe preparation for rapid small volume resuscitation. Its use is consistent with modern trends in intensive care and acute medicine.
METHODS AND RESULTS: In a multicentre clinical study the authors investigated the effect of a rapid infusion of a small volume of tensitone (4 ml/kg) on the restoration of basic haemodynamic parameters, diuresis and the general condition of 81 patients with massive traumatic or peroperative haemorrhage. As compared with the effect of standard volume expanders (N = 34), Tensitone had a markedly more rapid and more pronounced effect on the normalization of the blood pressure (p < 0.01), heart rate (p < 0.05), central venous pressure and diuresis (p < 0.01). The haemodynamic effects of Tensitone are almost immediate (rise of blood pressure within 10 minutes) while they are at the same time sufficiently protracted (for at least 2 hours). The tolerance and safety of treatment were very good, more serious undesirable effects (thrombophlebitis) were recorded only in 3.6% of the patients.
CONCLUSIONS: Tensitone is an effective and safe preparation for rapid small volume resuscitation. Its use is consistent with modern trends in intensive care and acute medicine.