[Guidelines for the therapeutic use of NSAIDs in pediatrics].

Nonsteroidal anti-inflammatory drugs (NSAIDs) have an expanding role in pediatrics. Currently only a low number of NSAIDs with a documented efficacy and tolerability is available for pediatric use. The most prescribed antiinflammatory drugs in children are propionic acid derivatives (ketoprofen lisyne salt), niflumic acid and nimesulide. Indications include treatment of inflammation associated to respiratory tract infections, fever, rheumatic disease and other chronic inflammatory conditions, peri/post-operative and cancer pain. NSAIDs are generally well tolerated with a low incidence of serious side effect. The aim of this work is to provide guidelines for a rationale use of NSAIDs in children, according to the different pathologies and the most recent clinical-experimental data.