Effect of antirheumatics and inhibitors of cyclooxygenase, lipoxygenases and thromboxane synthetase on cobra venom factor rat paw edema.

The cobra venom factor (CVF) rat paw edema was inhibited by cyclooxygenase (indomethacin, piroxicam, aspirin), lipoxygenase (BW 755c) and thromboxane synthetase (imidazole) inhibitors as well as by dexamethasone and, at high doses, by paracetamol and phenacetin. No definite results were obtained with slow acting antirheumatic drugs (D-penicillamine, levamisole, gold thiosulphate, chloroquine), since results varied considerably. The results are shortly discussed, with respect to the role of arachidonate lipoxygenase products as well as O-radicals.