Nature communications · 2023
Association between vmPFC gray matter volume and smoking initiation in adolescents.
СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Xiang Shitong, Jia Tianye, Xie Chao, Cheng Wei, Chaarani Bader, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Büchel Christian, Desrivières Sylvane, Flor Herta, Grigis Antoine, Gowland Penny A, Brühl Rüdiger, Martinot Jean-Luc, Martinot Marie-Laure Paillère, Nees Frauke, Orfanos Dimitri Papadopoulos, Poustka Luise, Hohmann Sarah, Fröhner Juliane H, Smolka Michael N, Vaidya Nilakshi, Walter Henrik, Whelan Robert, Garavan Hugh, Schumann Gunter, Sahakian Barbara J, Robbins Trevor W, Feng Jianfeng, IMAGEN Consortium
Аннотация
Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.