Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?

PURPOSE: The aim of this study was to evaluate the influence of LY300164 (an AMPA/kainate receptor antagonist) administered alone or in combination with valproate (VPA) or phenobarbital (PB) on body temperature in mice.

MATERIAL AND

METHODS

The temperature measurements were performed in Albino Swiss mice injected with the respective drugs by using a rectal thermistor thermometer.

RESULTS

LY300164, at the dose of 2 mg/kg, did not affect the body temperature of the examined animals. However, the combination of LY300164 (2 mg/kg) with VPA (165 mg/kg) resulted in a significant decrease in body temperature within 60-180 min after their peak of maximum anticonvulsant activity. Moreover, VPA (269 mg/kg) administered alone, evidently produced hypothermic effects at the times between 120-180 min after the peak of the maximum antiseizure effect. In contrast, phenobarbital administered alone or in combination with LY300164 did not affect the body temperature in the mice.

CONCLUSIONS

Hypothermia induced by LY 300164 combined with VPA may be useful in various central nervous system disease treatments.