Emerging infectious diseases · 2015
Microbiota that affect risk for shigellosis in children in low-income countries.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Lindsay Brianna, Oundo Joe, Hossain M Anowar, Antonio Martin, Tamboura Boubou, Walker Alan W, Paulson Joseph N, Parkhill Julian, Omore Richard, Faruque Abu S G, Das Suman Kumar, Ikumapayi Usman N, Adeyemi Mitchell, Sanogo Doh, Saha Debasish, Sow Samba, Farag Tamer H, Nasrin Dilruba, Li Shan, Panchalingam Sandra, Levine Myron M, Kotloff Karen, Magder Laurence S, Hungerford Laura, Sommerfelt Halvor, Pop Mihai, Nataro James P, Stine O Colin
Аннотация
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.