Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates.

We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic-clonic seizures produced by PTZ on mice was studied. All the compounds had the same pharmacological profile, they extended sleeping-time induced by sodium pentobarbital and showed protection against PTZ-induced convulsions, decreasing the death rate.