Veterinary anaesthesia and analgesia · 2021
Immobilization, cardiopulmonary and blood gas effects of ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine in free-ranging serval (Leptailurus serval).
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Blignaut Christiaan J, Steenkamp Gerhard, Loock Daan, Emslie Roxanne, Zeiler Gareth E
Аннотация
OBJECTIVE: To compare ketamine-butorphanol-medetomidine (KBM) with butorphanol-midazolam-medetomidine (BMM) immobilization of serval.
STUDY DESIGN: Blinded, randomized trial.
ANIMALS: A total of 23 captures [KBM: five females, six males; 10.7 kg (mean); BMM: 10 females, two males; 9.6 kg].
METHODS: Serval were cage trapped and immobilized using the assigned drug combination delivered via a blow dart into gluteal muscles. Prior to darting, a stress score was assigned (0: calm; to 3: markedly stressed). Drug combinations were dosed based on estimated body weights: 8.0, 0.4 and 0.08 mg kg-1 for KBM and 0.4, 0.3 and 0.08 mg kg-1 for BMM, respectively. Time to first handling, duration of anaesthesia and recovery times were recorded. Physiological variables including blood glucose and body temperature were recorded at 5 minute intervals. Atipamezole (5 mg mg-1 medetomidine) and naltrexone (2 mg mg-1 butorphanol) were administered intramuscularly prior to recovery. Data, presented as mean values, were analysed using general linear mixed model and Spearman's correlation (stress score, glucose, temperature); significance was p < 0.05.
RESULTS: Doses based on actual body weights were 8.7, 0.4 and 0.09 mg kg-1 for KBM and 0.5, 0.4 and 0.09 mg kg-1 for BMM, respectively. Time to first handling was 10.2 and 13.3 minutes for KBM and BMM, respectively (p = 0.033). Both combinations provided cardiovascular stability during anaesthesia that lasted a minimum of 35 minutes. Recovery was rapid and calm overall, but ataxia was noted in KBM. Stress score was strongly correlated to blood glucose (r2 = 0.788; p = 0.001) and temperature (r2 = 0.634; p = 0.015).
CONCLUSIONS AND CLINICAL RELEVANCE: Both combinations produced similar effective immobilization that was cardiovascularly stable in serval. Overall, BMM is recommended because it is fully antagonizable. A calm, quiet environment before drug administration is essential to avoid capture-induced hyperglycaemia and hyperthermia.
STUDY DESIGN: Blinded, randomized trial.
ANIMALS: A total of 23 captures [KBM: five females, six males; 10.7 kg (mean); BMM: 10 females, two males; 9.6 kg].
METHODS: Serval were cage trapped and immobilized using the assigned drug combination delivered via a blow dart into gluteal muscles. Prior to darting, a stress score was assigned (0: calm; to 3: markedly stressed). Drug combinations were dosed based on estimated body weights: 8.0, 0.4 and 0.08 mg kg-1 for KBM and 0.4, 0.3 and 0.08 mg kg-1 for BMM, respectively. Time to first handling, duration of anaesthesia and recovery times were recorded. Physiological variables including blood glucose and body temperature were recorded at 5 minute intervals. Atipamezole (5 mg mg-1 medetomidine) and naltrexone (2 mg mg-1 butorphanol) were administered intramuscularly prior to recovery. Data, presented as mean values, were analysed using general linear mixed model and Spearman's correlation (stress score, glucose, temperature); significance was p < 0.05.
RESULTS: Doses based on actual body weights were 8.7, 0.4 and 0.09 mg kg-1 for KBM and 0.5, 0.4 and 0.09 mg kg-1 for BMM, respectively. Time to first handling was 10.2 and 13.3 minutes for KBM and BMM, respectively (p = 0.033). Both combinations provided cardiovascular stability during anaesthesia that lasted a minimum of 35 minutes. Recovery was rapid and calm overall, but ataxia was noted in KBM. Stress score was strongly correlated to blood glucose (r2 = 0.788; p = 0.001) and temperature (r2 = 0.634; p = 0.015).
CONCLUSIONS AND CLINICAL RELEVANCE: Both combinations produced similar effective immobilization that was cardiovascularly stable in serval. Overall, BMM is recommended because it is fully antagonizable. A calm, quiet environment before drug administration is essential to avoid capture-induced hyperglycaemia and hyperthermia.