International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
High varicella zoster virus susceptibility in Caribbean island populations: Implications for vaccination.
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Vos Regnerus A, Mollema Liesbeth, van Boven Michiel, van Lier Alies, Smits Gaby, Janga-Jansen Alcira V A, Baboe-Kalpoe Sharda, Hulshof Koen, Stienstra Ymkje, van der Klis Fiona R M, de Melker Hester E
Аннотация
OBJECTIVES: Varicella zoster virus (VZV) infection is reported regularly among adolescents and adults in Caribbean island populations. The disease more often runs a severe course among these populations, causing a substantial burden. The aim of this sero-epidemiological study was to obtain an insight into VZV susceptibility and its determinants in island populations of the Caribbean Netherlands (CN).
METHODS: Participants from Bonaire, St. Eustatius, and Saba (n = 1829, aged 0-90 years) donated a blood sample and completed a questionnaire. VZV-specific IgG antibodies were determined using a bead-based multiplex immunoassay. Risk factors were analysed using a logistic regression model.
RESULTS: Overall seroprevalence in CN was 78%, being lowest on St. Eustatius (73%) and highest on Bonaire and Saba (79%). Seropositivity increased gradually with age, with 60% and 80% at ages 10 years and 30 years, respectively, and ranging between 80% and 90% thereafter. Higher odds for VZV seronegativity were seen among persons who were born in CN or had resided there since early childhood, and among single-person households.
CONCLUSIONS: VZV susceptibility is relatively high among adolescents and adults in CN. In order to reduce the burden of VZV-related disease in these populations, routine varicella vaccination is recommended. As data are scarce, the study findings can serve as a blueprint for the epidemiology in tropical regions.
METHODS: Participants from Bonaire, St. Eustatius, and Saba (n = 1829, aged 0-90 years) donated a blood sample and completed a questionnaire. VZV-specific IgG antibodies were determined using a bead-based multiplex immunoassay. Risk factors were analysed using a logistic regression model.
RESULTS: Overall seroprevalence in CN was 78%, being lowest on St. Eustatius (73%) and highest on Bonaire and Saba (79%). Seropositivity increased gradually with age, with 60% and 80% at ages 10 years and 30 years, respectively, and ranging between 80% and 90% thereafter. Higher odds for VZV seronegativity were seen among persons who were born in CN or had resided there since early childhood, and among single-person households.
CONCLUSIONS: VZV susceptibility is relatively high among adolescents and adults in CN. In order to reduce the burden of VZV-related disease in these populations, routine varicella vaccination is recommended. As data are scarce, the study findings can serve as a blueprint for the epidemiology in tropical regions.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAntibodies, ViralChildChild, PreschoolDisease SusceptibilityFemaleHerpesvirus 3, HumanHumansImmunoglobulin GInfantInfant, NewbornIslandsLogistic ModelsMaleMiddle AgedRisk FactorsSeroepidemiologic StudiesSurveys and QuestionnairesVaricella Zoster Virus InfectionViral VaccinesYoung Adult