Indian journal of medical microbiology · 2019
Institutional outbreak of varicella in a child welfare institute in Chandigarh, North India.
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Singh Mini P, Rungta Tripti, Kumar Archit, Goyal Kapil, Bharti Bhavneet, Ratho R K
Аннотация
INTRODUCTION: Varicella outbreaks are known to occur in developing nations as vaccine coverage is still low.
MATERIAL AND METHODS: In the present study, an institutional outbreak from Chandigarh, India, is reported wherein the utility of non-invasive samples such as saliva and urine was studied for the molecular diagnosis of varicella by conventional polymerase chain reaction (PCR), real-time PCR and real-time loop-mediated isothermal amplification (real-time LAMP).
RESULTS: The results of the present study showed that saliva and urine samples can be used for outbreak investigation of varicella compared to varicella-zoster virus DNA in vesicular swab samples with reasonable sensitivity.
CONCLUSION: Thus, molecular techniques may be useful in the early identification of the outbreak and timely isolation, and the treatment of cases can further prevent its spread.
MATERIAL AND METHODS: In the present study, an institutional outbreak from Chandigarh, India, is reported wherein the utility of non-invasive samples such as saliva and urine was studied for the molecular diagnosis of varicella by conventional polymerase chain reaction (PCR), real-time PCR and real-time loop-mediated isothermal amplification (real-time LAMP).
RESULTS: The results of the present study showed that saliva and urine samples can be used for outbreak investigation of varicella compared to varicella-zoster virus DNA in vesicular swab samples with reasonable sensitivity.
CONCLUSION: Thus, molecular techniques may be useful in the early identification of the outbreak and timely isolation, and the treatment of cases can further prevent its spread.