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DOI 10.18632/oncotarget.28541

Медицинская библиотека · Oncotarget · 2023

Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in brazil: Balancing efficacy, safety, and tolerability.

Xavier Flávia Dias, Farias Danielle Leão Cordeiro de, Neto Abrahão Elias Hallack, Ribeiro Glaciano Nogueira, Araujo Marco Aurelio Salvino de, Carneiro Thiago Xavier, Baiocchi Otavio Cesar Carvalho Guimarães

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Аннотация

IMPORTANCE

Cognitive impairment is associated with poor outcomes in inpatient rehabilitation (IPR) but may be underrecognized among patients without neurologic diagnoses.

OBJECTIVE

To compare cognitive impairment prevalence between IPR patients with ischemic stroke and patients with Type II diabetes mellitus (T2DM) without a cerebrovascular diagnosis and to examine associations with functional outcomes and readmissions.

DESIGN

This observational, cross-sectional study used retrospective electronic medical record data collected from 2019 to 2022.

SETTING

Single inpatient rehabilitation facility in an academic health system.

PARTICIPANTS

The sample consisted of 360 patients admitted to IPR, including 147 patients with ischemic stroke without T2DM and 213 patients with T2DM without a neurologic diagnosis.

OUTCOMES AND MEASURES: Cognitive status was assessed at admission using the Montreal Cognitive Assessment (MoCA). Outcomes included discharge self-care and mobility (Section GG), within-stay readmission, and 30-day postdischarge readmission.

RESULTS

Mild cognitive impairment was more prevalent among patients with T2DM than among patients with stroke at admission. Patients with stroke had lower mean MoCA scores at admission and discharge. Diagnosis was not associated with discharge self-care, discharge mobility, or readmission outcomes. Higher admission functional status and lower disease burden were associated with better functional outcomes, and higher admission mobility was associated with lower odds of within-stay readmission.

CONCLUSIONS AND RELEVANCE: Routine, diagnosis-agnostic cognitive screening identified high rates of cognitive impairment across diagnostic groups in IPR. Occupational therapy practitioners should incorporate systematic cognitive screening and follow-up functional cognition assessment to guide intervention planning and discharge preparation. Plain-Language Summary: Many people receiving inpatient rehabilitation experience problems with thinking and memory that can affect daily activities and recovery. These problems are often expected after stroke but may be overlooked in people with other health conditions, such as diabetes. This study compared cognitive impairment and rehabilitation outcomes in people with stroke and people with Type II diabetes who did not have a stroke. The study found that mild cognitive impairment was common in both groups, including many people with diabetes. Whether a person had a stroke or diabetes did not explain differences in functional outcomes or hospital readmissions. Instead, a person's functional ability at admission and overall health burden were more strongly related to outcomes. These findings suggest that occupational therapy practitioners should routinely screen cognition for all patients in inpatient rehabilitation, not only those with neurologic diagnoses. Early identification of cognitive challenges can support therapy planning, daily functioning, and safe discharge.

Для цитирования: Xavier Flávia Dias, Farias Danielle Leão Cordeiro de, Neto Abrahão Elias Hallack, Ribeiro Glaciano Nogueira, Araujo Marco Aurelio Salvino de, Carneiro Thiago Xavier, Baiocchi Otavio Cesar Carvalho Guimarães. Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in brazil: Balancing efficacy, safety, and tolerability.. Oncotarget. 2023. DOI: 10.18632/oncotarget.28541.

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